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Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19.
Baldi, Federico; Dentone, Chiara; Mikulska, Malgorzata; Fenoglio, Daniela; Mirabella, Michele; Magnè, Federica; Portunato, Federica; Altosole, Tiziana; Sepulcri, Chiara; Giacobbe, Daniele Roberto; Uras, Chiara; Scavone, Graziana; Taramasso, Lucia; Orsi, Andrea; Cittadini, Giuseppe; Filaci, Gilberto; Bassetti, Matteo.
  • Baldi F; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
  • Dentone C; Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy.
  • Mikulska M; Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy.
  • Fenoglio D; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
  • Mirabella M; Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy.
  • Magnè F; Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
  • Portunato F; Biotherapy Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy.
  • Altosole T; Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy.
  • Sepulcri C; Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy.
  • Giacobbe DR; Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy.
  • Uras C; Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
  • Scavone G; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
  • Taramasso L; Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy.
  • Orsi A; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
  • Cittadini G; Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy.
  • Filaci G; Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
  • Bassetti M; Biotherapy Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy.
Front Med (Lausanne) ; 9: 1062450, 2022.
Article in English | MEDLINE | ID: covidwho-2227870
ABSTRACT
COVID-19 in immunocompromised patients is difficult to treat. SARS-CoV-2 interaction with the host immune system and the role of therapy still remains only partly understood. There are no data regarding the use of monoclonal antibodies and the combination of two antivirals in fighting viral replication and disease progression. We report the cases of two patients, both treated with rituximab for non-Hodgkin lymphoma and granulomatosis with polyangiitis, respectively, and both hospitalized for COVID-19 with positive SARS-CoV-2 RNAemia, who were successfully treated with a salvage combination therapy with sotrovimab, remdesivir and nirmatrelvir/ritonavir.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report Language: English Journal: Front Med (Lausanne) Year: 2022 Document Type: Article Affiliation country: Fmed.2022.1062450

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report Language: English Journal: Front Med (Lausanne) Year: 2022 Document Type: Article Affiliation country: Fmed.2022.1062450