The relationship between plasminogen activator inhibitor-1 levels and the course of disease in COVID-19 patients
Turkish Journal of Biochemistry
; 47(5):672-679, 2022.
Article
in English
| EMBASE | ID: covidwho-2227885
ABSTRACT
Objectives:
Studies have shown that fibrinolysis activity is insufficient in COVID-19 patients. Plasminogen activator inhibitor-1 (PAI-1) is an important antifibrinolytic molecule that plays a key role in the fibrinolytic system. In our study;we aimed to evaluate serum PAI-1 and other biochemical parameters of COVID-19 patients in terms of disease course and mortality. Method(s) A total of 40 COVID-19 patients were hospitalized in the service and intensive care unit (ICU) of our hospital from October to December 2020 and 20 healthy volunteers were included in our study. The patients were grouped as those who transferred to the ICU from the service and transferred to service from the ICU. The first and second values of the same patients in both the service and the ICU were analyzed by SPSS. Result(s) The PAI-1 levels of the patients in the ICU were significantly higher than the levels of the same patients in the service and the healthy control group (p<0.001). IL-6, ferritin, and D-dimer levels in the ICU of the same patients were significantly higher than the levels of service and healthy control group (p<0.001). A positive correlation was found between initial serum PAI-1 and D-dimer levels in patients hospitalized in the service (p=0.039) and initial serum ferritin and IL-6 levels in the ICU (p=0.031). Conclusion(s) In our study, we found that PAI-1 levels increased significantly with the increase in mortality in COVID-19 patients. Copyright © 2022 the author(s), published by De Gruyter.
biochemical; covid-19; fibrinolysis; mortality; pai-1; adult; aged; article; breathing rate; clinical article; controlled study; coronavirus disease 2019; diagnostic test accuracy study; disease course; dyspnea; enzyme linked immunosorbent assay; female; Horowitz index; human; intensive care unit; male; middle aged; prospective study; protein expression; receiver operating characteristic; respiratory distress; reverse transcription polymerase chain reaction; sensitivity and specificity; survival; D dimer/ec [Endogenous Compound]; ferritin/ec [Endogenous Compound]; interleukin 6/ec [Endogenous Compound]; plasminogen activator inhibitor 1/ec [Endogenous Compound]; chemical analyzer; diagnostic kit; ELISA kit; immunoassay analyzer; microplate reader; microplate washer; polymerase chain reaction system; reverse transcriptase PCR assay kit; au480; Biospeedy; D dimer assay kit; elx50; ELx500
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Prognostic study
Language:
English
Journal:
Turkish Journal of Biochemistry
Year:
2022
Document Type:
Article
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