COVID-19 -Associated vasculitis in children: The case series, confirmed by tissue RT-PCR
International Journal of Rheumatic Diseases
; 26(Supplement 1):189-190, 2023.
Article
in English
| EMBASE | ID: covidwho-2228058
ABSTRACT
Background:
COVID-19 is still changing problem for pediatric rheumatologist, not only related with multisystem inflammatory syndrome. SARS-CoV- 2 can damage blood vessel endothelium through direct invasion, immune system dysregulation (hyperproduction of pro-inflammatory cytokines, interferonopathy) and hypercoagulation, and in this way triggers vasculitis. There are some data in the literature about skin vasculitis, central nervous system vasculopathy, associated with COVID-19 in children, but data are scarce. The aim of our study was to describe the cases, associated with COVID-19 in children. Method(s) in the retrospective-prospective case series study we included information about five children with COVID-19 associated vasculitis. In every case we have morphological description and the etiology was confirmed by RT-PCR in tissue biopsy. Result(s) The patients' demography, type of SARS-CoV- 2 identification, disease characteristics are in the tables 1-2. All patients required systemic corticosteroids and immunosuppression to control inflammation and recovering tissue damage.
case report; case study; child; clinical article; conference abstract; coronavirus disease 2019; demography; female; human; immunosuppressive treatment; inflammation; male; nonhuman; prospective study; retrospective study; Severe acute respiratory syndrome coronavirus 2; tissue injury; vasculitis; corticosteroid
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Language:
English
Journal:
International Journal of Rheumatic Diseases
Year:
2023
Document Type:
Article
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