Interleukin-17 and the COVID-19 cytokine storm: Cases reports
International Journal of Innovation and Applied Studies
; 38(3):524-528, 2023.
Article
in English
| ProQuest Central | ID: covidwho-2228299
ABSTRACT
We report two cases of patients with COVID-19. Clinical and biological features of the two patients confirm severe form of COVID-19 associated with cytokine storm. High levels of IL-6 and IL-17 were found. Unfortunately the patients died because of the multi-organ failure secondary to the cytokine storm. Cytokine storm is a systemic inflammatory syndrome which leads to aberrant release of cytokines. IL-6 is the most frequently reported cytokine to be increased in COVID-19 patients. Naive T CD4+ cells in the presence of TGF ß and IL-6 will differentiate into T helper 17 cells responsible for secreting IL-17A and 17F, target macrophages, dendritic cells, endothelial cells, and fibroblasts to increase the production of cytokines. IL-6 and IL-17 have been shown to play a role in increasing risk of airway disease. They synergistically promote viral persistence by protecting virus-infected cells from apoptosis. Immune hyperactivation in cytokine storm amplified levels of cytokines that will have systemic effects and cause collateral damage to vital organ systems. Immunotherapy can play a crucial role in COVID-19 managing. Tocilizumab an anti-IL6 receptor antibody was used with clinical improvement. The possibility of inhibiting IL17 as therapy for COVID-19 should be also considered.
Sciences: Comprehensive Works; Laboratories; Antibodies; Pathogens; Ventilators; Cytokine storm; Severe acute respiratory syndrome coronavirus 2; Vitamin C; Hospitals; Dyspnea; Fever; Viral diseases; Blood; Oxygen saturation; Proteins; COVID-19; Patients; Anemia; Dendritic cells; Fibroblasts; Endothelial cells; Respiratory distress syndrome; Interleukin; Cytokines; Apoptosis; Macrophages; Respiratory diseases; Coronaviruses
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Collection:
Databases of international organizations
Database:
ProQuest Central
Type of study:
Prognostic study
Language:
English
Journal:
International Journal of Innovation and Applied Studies
Year:
2023
Document Type:
Article
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