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COVID-19: Has the Liver Been Spared?
Brandi, Nicolò; Spinelli, Daniele; Granito, Alessandro; Tovoli, Francesco; Piscaglia, Fabio; Golfieri, Rita; Renzulli, Matteo.
  • Brandi N; Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, Italy.
  • Spinelli D; Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, Italy.
  • Granito A; Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  • Tovoli F; Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  • Piscaglia F; Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  • Golfieri R; Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, Italy.
  • Renzulli M; Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, Italy.
Int J Mol Sci ; 24(2)2023 Jan 06.
Article in English | MEDLINE | ID: covidwho-2228328
ABSTRACT
The liver is a secondary and often collateral target of COVID-19 disease but can lead to important consequences. COVID-19 might directly cause a high number of complications in patients with pre-existing chronic liver disease, increasing their risk of hepatic decompensation. Moreover, it also determines indirect consequences in the management of patients with liver disease, especially in those suffering from decompensated cirrhosis and HCC, as well as in the execution of their follow-up and the availability of all therapeutic possibilities. Liver imaging in COVID-19 patients proved to be highly nonspecific, but it can still be useful for identifying the complications that derive from the infection. Moreover, the recent implementation of telemedicine constitutes a possible solution to both the physical distancing and the re-organizational difficulties arising from the pandemic. The present review aims to encompass the currently hypothesized pathophysiological mechanisms of liver injury in patients with COVID-19 mediated by both the direct invasion of the virus and its indirect effects and analyze the consequence of the pandemic in patients with chronic liver disease and liver tumors, with particular regard to the management strategies that have been implemented to face this worldwide emergency and that can be further improved.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Carcinoma, Hepatocellular / COVID-19 / Liver Neoplasms Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Ijms24021091

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Carcinoma, Hepatocellular / COVID-19 / Liver Neoplasms Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Ijms24021091