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Huashi baidu granule in the treatment of pediatric patients with mild coronavirus disease 2019: A single-center, open-label, parallel-group randomized controlled clinical trial
Frontiers in pharmacology ; 14, 2023.
Article in English | EuropePMC | ID: covidwho-2228796
ABSTRACT

Background:

Since late February 2022, a wave of coronavirus disease 2019 (COVID-19) mainly caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant rapidly appeared in Shanghai, China. Traditional Chinese medicine treatment is recommended for pediatric patients;however, the safety and efficacy remain to be confirmed. We conducted a single-center, open-label, parallel-group randomized controlled trial to assess the efficacy and safety of a Chinese herb compound, Huashi Baidu granule (HSBDG) in pediatric patients with laboratory-confirmed mild COVID-19.

Methods:

108 recruited children (aged 3–18 years) with laboratory-confirmed mild COVID-19 were randomly allocated 21 to receive oral HSBDG for five consecutive days (intervention group) and to receive compound pholcodine oral solution for five consecutive days (control group). The negative conversion time of SARS-CoV-2 nucleic acid and symptom scores were recorded.

Results:

The median negative conversion time of SARS-CoV-2 nucleic acid was significantly shorter in the intervention group than in the control group (median days [interquartile range (IQR)] 3 [3–5] vs. 5 [3–6];p = 0.047). The median total symptom score on day 3 was significantly lower in the intervention group than in the control group (median total symptom score [IQR] 1 [0–2] vs. 2 [0–3];p = 0.036). There was no significant differences in the frequency of antibiotic use and side effects between the two groups.

Conclusion:

HSBDG is a safe, effective oral Chinese herbal compound granule, which shows a good performance within the Omicron wave among pediatric patients.
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Collection: Databases of international organizations Database: EuropePMC Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid / Traditional medicine / Variants Language: English Journal: Frontiers in pharmacology Year: 2023 Document Type: Article

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Collection: Databases of international organizations Database: EuropePMC Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid / Traditional medicine / Variants Language: English Journal: Frontiers in pharmacology Year: 2023 Document Type: Article