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COVID-19: Understanding the impact of anti-hypertensive drugs and hydroxychloroquine on the ACE1 and ACE2 in lung and adipose tissue in SHR and WKY rats.
Corrêa, Beatriz Santos Geoffroy; de Barros, Silvana; Vaz, Julia Braga; Peres, Maria Angelica; Uchiyama, Mayara Klimuk; da Silva, Alexandre Alves; Furukawa, Luzia Naoko Shinohara.
  • Corrêa BSG; Laboratory of Renal Pathophysiology, Department of Internal Medicine, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • de Barros S; Hypertension Unit, Renal Division, General Hospital of School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Vaz JB; Laboratory of Renal Pathophysiology, Department of Internal Medicine, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Peres MA; Laboratory of Renal Pathophysiology, Department of Internal Medicine, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Uchiyama MK; Laboratory of Supramolecular Chemistry & Nanotechnology, Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
  • da Silva AA; Department of Physiology and Biophysics, University of Mississippi Medical Center Jackson, Jackson, Mississippi, USA.
  • Furukawa LNS; Laboratory of Renal Pathophysiology, Department of Internal Medicine, School of Medicine, University of São Paulo, São Paulo, Brazil.
Physiol Rep ; 11(3): e15598, 2023 02.
Article in English | MEDLINE | ID: covidwho-2229083
ABSTRACT
Hypertensive individuals taking anti-hypertensive drugs from renin-angiotensin system inhibitors may exhibit a more severe evolution of the disease when contracting the SARS-CoV-2 virus (COVID-19 disease) due to potential increases in ACE2 expression. The study investigated ACE1 and ACE2 axes and hydroxychloroquine in the lungs and adipose tissue of male and female normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHRs). SHRs were treated with losartan (10 mg/kg/day) or captopril (10 mg/kg/day) for 14 days or 7 days with hydroxychloroquine (200 mg/kg/day) in drinking water. WKY rats were also treated for 7 days with hydroxychloroquine. Blood pressure (BP), protein, and mRNA expression of ACE1 and ACE2 were analyzed in serum, adipose, and lung tissues. Losartan and captopril reduced BP in both sexes in SHR, whereas hydroxychloroquine increased BP in WKY rats. Losartan reduced ACE2 in serum and lungs in both sexes and in adipose tissue of male SHRs. Captopril decreased ACE2 protein in the lung of females and in adipose tissue in both sexes of SHRs. Hydroxychloroquine decreased ACE1 and ACE2 proteins in the lungs in both sexes and adipose tissue in male SHRs. In female WKY rats, ACE2 protein was lower only in the lungs and adipose tissue. Losartan effectively inhibited ACE2 in male and captopril in female SHRs. Hydroxychloroquine inhibited ACE2 in male SHRs and female WKY rats. These results further our understanding of the ACE2 mechanism in patients under renin-angiotensin anti-hypertensive therapy and in many trials using hydroxychloroquine for COVID-19 treatment and potential sex differences in response to drug treatment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hypertension Type of study: Experimental Studies Limits: Animals / Female / Humans / Male Language: English Journal: Physiol Rep Year: 2023 Document Type: Article Affiliation country: Phy2.15598

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hypertension Type of study: Experimental Studies Limits: Animals / Female / Humans / Male Language: English Journal: Physiol Rep Year: 2023 Document Type: Article Affiliation country: Phy2.15598