Vaccines, adjuvants and key factors for mucosal immune response.
Immunology
; 167(2): 124-138, 2022 10.
Article
in English
| MEDLINE | ID: covidwho-2229084
ABSTRACT
Vaccines are the most effective tool to control infectious diseases, which provoke significant morbidity and mortality rates. Most vaccines are administered through the parenteral route and can elicit a robust systemic humoral response, but they induce a weak T-cell-mediated immunity and are poor inducers of mucosal protection. Considering that most pathogens enter the body through mucosal surfaces, a vaccine that elicits protection in the first site of contact between the host and the pathogen is promising. However, despite the advantages of mucosal vaccines as good options to confer protection on the mucosal surface, only a few mucosal vaccines are currently approved. In this review, we discuss the impact of vaccine administration in different mucosal surfaces; how appropriate adjuvants enhance the induction of protective mucosal immunity and other factors that can influence the mucosal immune response to vaccines.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vaccines
/
Immunity, Mucosal
Topics:
Vaccines
Language:
English
Journal:
Immunology
Year:
2022
Document Type:
Article
Affiliation country:
Imm.13526
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