Beneficial effects of prehospital use of statins in a large United States cohort of hospitalized coronavirus disease 2019 patients.
J Cardiovasc Med (Hagerstown)
; 24(3): 172-183, 2023 03 01.
Article
in English
| MEDLINE | ID: covidwho-2229135
ABSTRACT
AIMS:
This large cohort study aimed to assess the role of chronic statin use on COVID-19 disease severity.METHODS:
An observational retrospective study from electronic medical records of hospitalized patients (nâ=â43â950) with COVID-19 between January and September 2020 in 185 hospitals in the United States. A total of 38â875 patients met inclusion criteria; 23â066 were included in the propensity-matched sampling with replacement cohort; 11â533 were prehospital statin users. The primary outcome was all-cause death; secondary outcomes were death from COVID-19 and serious complications. Mean, standard deviation, chi-square test, Student's t-test, linear regression, and binary and multinomial logistic regressions were used for statistical analysis.RESULTS:
Among 38â875 patients, 30% were chronic statin users [mean age, 70.82 (±12.25); 47.1% women] and 70% were statin nonusers [mean age, 58.44 (±18.27); 48.5% women]. Key propensity-matched outcomes among 11â533 chronic statin users showed 20% lower risk of all-cause mortality (OR 0.80, 95% CI 0.74-0.86, Pâ<â0.001), 23% lower risk of mortality from COVID-19 (OR 0.77, 95% CI 0.71-0.84, Pâ<â0.001), 16% lower risk of ICU admission (OR 0.84, 95% CI 0.79-0.89, Pâ<â0.001), 24% lower risk of critical acute respiratory distress syndrome with COVID-19 (OR 0.76, 95% CI 0.70-0.83, Pâ<â0.001), 23% lower risk of mechanical ventilation (OR 0.77, 95% CI 0.71-0.82, Pâ<â0.001), 20% lower risk of severe sepsis with septic shock (OR 0.80, 95% CI 0.67-0.93, Pâ=â0.004), shorter hospital length of stay [9.87 (±8.94), Pâ<â0.001] and brief duration of mechanical ventilation [8.90 (±8.94), Pâ<â0.001].CONCLUSION:
Chronic use of statins is associated with reduced mortality and improved clinical outcomes in patients hospitalized for COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Emergency Medical Services
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
North America
Language:
English
Journal:
J Cardiovasc Med (Hagerstown)
Journal subject:
Vascular Diseases
/
Cardiology
Year:
2023
Document Type:
Article
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