Conradi-Hünerman-Happle Syndrome and Obsessive-Compulsive Disorder: a clinical case report.
BMC Psychiatry
; 23(1): 87, 2023 02 06.
Article
in English
| MEDLINE | ID: covidwho-2229346
ABSTRACT
BACKGROUND:
Obsessive-Compulsive Disorder (OCD) is a common and chronic psychiatric disorder with significant morbidity characterized by intrusive, uncontrollable and reoccurring thoughts (i.e., obsessions) and/or ritualistic behaviours (i.e., compulsions). Conradi-Hünerman-Happle Syndrome (CHHS) is a rare inherited X-linked dominant variant of chondrodysplasia punctata, a heterogeneous group of rare bone dysplasias characterized by punctate epiphyseal calcifications of complex etiology and pathophysiology that remain to be defined. Available literature reveals a lacuna in regards to the coexistence of the entities with no clinical reports described. CASE PRESENTATION A 12 year old female patient with diagnosis of CHHS, presents to psychiatric consultation due to aggravation of her OCD clinical picture, with aggravation of hand-washing frequency during the Covid-19 pandemic with significant functional impact. Psychopharmacological treatment aimed at OCD with Selective Serotonin Reuptake Inhibitor (SSRI) and antipsychotic was instituted with favourable, albeit partial response.CONCLUSIONS:
The authors aim to describe a clinical case in which the patient presents with Conradi-Hünerman-Happle Syndrome and Obsessive-Compulsive Disorder. Clinical descriptions of CHHS and OCD are not available in the literature. Through this case description the authors aim to present a rare case as well as discuss an eventual association between etiology and/or pathophysiology of the two disorders.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Chondrodysplasia Punctata
/
COVID-19
/
Obsessive-Compulsive Disorder
Type of study:
Case report
/
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Qualitative research
Topics:
Long Covid
/
Variants
Limits:
Child
/
Female
/
Humans
Language:
English
Journal:
BMC Psychiatry
Journal subject:
Psychiatry
Year:
2023
Document Type:
Article
Affiliation country:
S12888-023-04579-1
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