Evaluation of Side Effects After Heterologous Vaccination with BNT162b2 Vaccine in Healthcare Workers Vaccinated with Two Doses of Inactive COVID-19 Vaccine.
Klimik Dergisi
; 35(4):238-243, 2022.
Article
in Turkish
| EMBASE | ID: covidwho-2229421
ABSTRACT
Objective:
Vaccination is the most effective way to control the COVID-19 pandemic all over the world. We aimed to evaluate the relationship between antibody titers and vaccine side effects after the BNT162b2 vaccine was administered as a reminder dose in healthcare workers (HCW) who received two doses of inactivated SARS-CoV-2 vaccine name CoronaVac (Sinovac Life Sciences, Beijing, China). Method(s) A total of 428 HCWs participated in the study. Participants who received the mRNA vaccine as a reminder dose were evaluated with a questionnaire regarding antibody values and vaccine side effects. Three weeks after the first BNT162b2 vaccine, the same questionnaire was applied face-to-face to HCW, and the same questionnaire was applied to those who received a second reminder dose via telephone. Result(s) Out of 428, 373 (87.1%) HCWs preferred one and 55 (12.9%) two doses of the BNT162b2 vaccine as reminder doses after being vaccinated with an inactivated vaccine. It was observed that side effects were more frequent in women aged 18-40 after a single dose of the BNT162b2 vaccine (p<0.001). The most common side effects are redness, swelling, and pain at the injection site, with a rate of 59.6%. Fatigue-weakness was the most common systemic reaction, with a rate of 58.6%. Axillary lymphadenopathy was observed seen in 3 (1.1%) HCWs. The median value of IgG titers in the third week after the reminder dose was found to be higher in HCW with side effects than those without side effects (p<0.001). When the cumulative incidence rate of vaccinated people was evaluated over 389 people, no cases were observed on the 14th and 30th days after the first reminder dose of BNT162b2. However, the first case was observed on the 60th day, and after the second reminder dose, cases were seen on the 14th, 30th, and 60th days. Conclusion(s) Since the side effects detected after the BNT162b2 reminder dose were mild to moderate and progressed with local symptoms, it was concluded that highly protective mRNA vaccines could be safely preferred for protection from COVID-19. Copyright © 2022, DOC Design and Informatics Co. Ltd.. All rights reserved.
antibody titer; BNT162b2 vaccine; healthcare workers; heterologous vaccination; side effects; adult; article; axillary lymph node; fatigue/si [Side Effect]; female; health care personnel; human; injection site pain/si [Side Effect]; injection site reaction/si [Side Effect]; injection site swelling/si [Side Effect]; lymphadenopathy/si [Side Effect]; major clinical study; questionnaire; side effect; vaccination; weakness/si [Side Effect]; coronavac; tozinameran/ae [Adverse Drug Reaction]; injection site redness/si [Side Effect]; bnt 162 b 2
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Observational study
/
Qualitative research
Topics:
Vaccines
Language:
Turkish
Journal:
Klimik Dergisi
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS