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Favipiravir for symptomatic COVID-19: A nationwide observational cohort study.
Doi, Yohei; Ishihara, Takuma; Banno, Sumi; Ando, Masahiko; Kondo, Masashi.
  • Doi Y; Departments of Microbiology and Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: yoheidoi@fujita-hu.ac.jp.
  • Ishihara T; Innovative and Clinical Research Promotion Center, Gifu University Hospital, Yanagido, Gifu, Japan.
  • Banno S; Center for Clinical Trial and Research Support, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
  • Ando M; Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Aichi, Japan.
  • Kondo M; Center for Clinical Trial and Research Support, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; Department of Respiratory Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
J Infect Chemother ; 2022 Oct 26.
Article in English | MEDLINE | ID: covidwho-2229544
ABSTRACT

INTRODUCTION:

Favipiravir, an antiviral agent with activity against SARS-CoV-2, was made available to hospitals in Japan for off-label use among COVID-19 patients between 2020 and 2021.

METHODS:

A nationwide observational cohort study was conducted on patients who received favipiravir as part of clinical care between February 2020 and December 2021. Information was collected on demographics, comorbidities, severity of illness, use of favipiravir and other medications targeting COVID-19, adverse events, clinical status at 7 and 14 days and clinical outcome one month after admission to the hospital.

RESULTS:

A total of 17,508 hospitalized patients who received favipiravir were registered from 884 hospitals. In terms of demographics, 55.9% were age ≥60 years, and 62.3% were male. At least one of the four surveyed comorbidities was present in 45.5% of the patients. The rates of clinical improvement at 7 and 14 days were 72.4% and 87.5%, 61.4% and 76.6%, and 45.4% and 59.5% for mild, moderate, and severe diseases, respectively. The case fatality rates within a month from hospitalization were 3.3%, 12.6%, and 29.1% for mild, moderate, and severe diseases, respectively. Significant correlations were observed between death and advanced age, male sex, moderate or severe disease, diabetes, cardiovascular diseases, and immunosuppression. Commonly reported adverse events included uric acid level increase or hyperuricemia (16.8%), liver function abnormalities (6.9%), and rash (1.0%).

CONCLUSIONS:

Favipiravir was well tolerated among COVID-19 patients. The study provides insights into the use of this agent at hospitals across Japan in the early phase of the pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal subject: Microbiology / Drug Therapy Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal subject: Microbiology / Drug Therapy Year: 2022 Document Type: Article