More Than Meets the Eye: Orbital Swelling in an Adolescent with Sickle Cell Disease
International Journal of Hematology-Oncology and Stem Cell Research
; 17(1):56-62, 2023.
Article
in English
| EMBASE | ID: covidwho-2230941
ABSTRACT
Periorbital swelling is a clinical presentation with a broad differential and potentially deleterious consequence. Causes range from benign, including allergic reaction, to vision-and life-threatening, including orbital cellulitis and orbital infarction. The recent climate of SARS-CoV-2 has further complicated this differential, as the virus poses broad clinical presentations with new manifestations reported frequently. Rapid identification of the underlying etiology is crucial, as treatment approaches diverge greatly. Here, we report the case of an African American adolescent male with a history of homozygous sickle cell anemia presenting to an inner city hospital with bilateral periorbital swelling amid the coronavirus pandemic. Differentials including orbital cellulitis, COVID-MIS-C, orbital inflammatory syndrome, Hoagland sign, and orbital infarction secondary to sickle cell crisis are contrasted. We contrast our case with 12 case reports of orbital infarction in the setting of sickle cell crisis within the past 10 years, highlighting how these presentations, along with commonly reported findings of orbital infarction, compare with our patient. Copyright © 2022 Tehran University of Medical Sciences.
Adolescent; Orbital edema; Orbital edema etiology; Sickle cell disease; acute chest syndrome; African American; analgesia; anemia; article; backache; blood cell count; blood culture; case report; clinical article; computer assisted tomography; echocardiography; electrocardiogram; erythrocyte sedimentation rate; erythrocyte transfusion; fever; follow up; Gram positive cocci; hospital discharge; hospitalization; human; hydration; hypertension; leukocytosis; male; microcytic anemia; nuclear magnetic resonance imaging; orbit tumor; pericardial effusion; polymerase chain reaction; posterior reversible encephalopathy syndrome; proteinuria; respiratory tract disease; shoulder pain; sickle cell anemia; sickle cell crisis; sinus tachycardia; tachycardia; thorax radiography; thyroid function test; urinalysis; urine culture; visual acuity; amino terminal pro brain natriuretic peptide/ec [Endogenous Compound]; C reactive protein/ec [Endogenous Compound]; hydroxyurea/pv [Special Situation for Pharmacovigilance]; lactate dehydrogenase/ec [Endogenous Compound]; oxycodone/pv [Special Situation for Pharmacovigilance]; oxycodone/tm [Unexpected Outcome of Drug Treatment]; paracetamol/pv [Special Situation for Pharmacovigilance]; paracetamol/tm [Unexpected Outcome of Drug Treatment]; troponin/ec [Endogenous Compound]
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Etiology study
/
Prognostic study
Language:
English
Journal:
International Journal of Hematology-Oncology and Stem Cell Research
Year:
2023
Document Type:
Article
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