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SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination.
Castruita, Jose Alfredo Samaniego; Schneider, Uffe Vest; Mollerup, Sarah; Leineweber, Thomas Daell; Weis, Nina; Bukh, Jens; Pedersen, Martin Schou; Westh, Henrik.
  • Castruita JAS; Department of Clinical Microbiology, Copenhagen University Hospital Amager-Hvidovre, Hvidovre, Denmark.
  • Schneider UV; Department of Clinical Microbiology, Copenhagen University Hospital Amager-Hvidovre, Hvidovre, Denmark.
  • Mollerup S; Department of Clinical Microbiology, Copenhagen University Hospital Amager-Hvidovre, Hvidovre, Denmark.
  • Leineweber TD; Department of Clinical Microbiology, Copenhagen University Hospital Amager-Hvidovre, Hvidovre, Denmark.
  • Weis N; Department of Infectious Diseases, Copenhagen University Hospital Amager-Hvidovre, Hvidovre, Denmark.
  • Bukh J; Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Pedersen MS; Department of Infectious Diseases, Copenhagen University Hospital Amager-Hvidovre, Hvidovre, Denmark.
  • Westh H; Copenhagen Hepatitis C Program (CO-HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
APMIS ; 131(3): 128-132, 2023 Mar.
Article in English | MEDLINE | ID: covidwho-2231536
ABSTRACT
In Denmark, vaccination against Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has been with the Pfizer-BioNTech (BTN162b2) or the Moderna (mRNA-1273) mRNA vaccines. Patients with chronic hepatitis C virus (HCV) infection followed in our clinic received mRNA vaccinations according to the Danish roll-out vaccination plan. To monitor HCV infection, RNA was extracted from patient plasma and RNA sequencing was performed on the Illumina platform. In 10 of 108 HCV patient samples, full-length or traces of SARS-CoV-2 spike mRNA vaccine sequences were found in blood up to 28 days after COVID-19 vaccination. Detection of mRNA vaccine sequences in blood after vaccination adds important knowledge regarding this technology and should lead to further research into the design of lipid-nanoparticles and the half-life of these and mRNA vaccines in humans.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hepatitis C / Hepatitis C, Chronic / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: APMIS Journal subject: Allergy and Immunology / Microbiology / Pathology Year: 2023 Document Type: Article Affiliation country: Apm.13294

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hepatitis C / Hepatitis C, Chronic / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: APMIS Journal subject: Allergy and Immunology / Microbiology / Pathology Year: 2023 Document Type: Article Affiliation country: Apm.13294