Your browser doesn't support javascript.
Waning of first- and second-dose ChAdOx1 and BNT162b2 COVID-19 vaccinations: a pooled target trial study of 12.9 million individuals in England, Northern Ireland, Scotland and Wales.
Kerr, Steven; Bedston, Stuart; Bradley, Declan T; Joy, Mark; Lowthian, Emily; Mulholland, Rachel M; Akbari, Ashley; Hobbs, F D Richard; Katikireddi, Srinivasa Vittal; de Lusignan, Simon; Rudan, Igor; Torabi, Fatemeh; Tsang, Ruby S M; Lyons, Ronan A; Robertson, Chris; Sheikh, Aziz.
  • Kerr S; Centre for Medical Informatics, Usher Institute, The University of Edinburgh, Edinburgh, UK.
  • Bedston S; Population Data Science, Swansea University Medical School, Swansea University, Swansea, UK.
  • Bradley DT; School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
  • Joy M; Public Health Agency, Belfast, UK.
  • Lowthian E; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Mulholland RM; Population Data Science, Swansea University Medical School, Swansea University, Swansea, UK.
  • Akbari A; Department of Education and Childhood Studies, Swansea University, Swansea, UK.
  • Hobbs FDR; Centre for Medical Informatics, Usher Institute, The University of Edinburgh, Edinburgh, UK.
  • Katikireddi SV; Population Data Science, Swansea University Medical School, Swansea University, Swansea, UK.
  • de Lusignan S; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Rudan I; MRC/CSO Social & Public Health Sciences Unit, University of Glasgow, Glasgow, UK.
  • Torabi F; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Tsang RSM; Centre for Medical Informatics, Usher Institute, The University of Edinburgh, Edinburgh, UK.
  • Lyons RA; Population Data Science, Swansea University Medical School, Swansea University, Swansea, UK.
  • Robertson C; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Sheikh A; Population Data Science, Swansea University Medical School, Swansea University, Swansea, UK.
Int J Epidemiol ; 2022 Oct 22.
Article in English | MEDLINE | ID: covidwho-2231783
ABSTRACT

BACKGROUND:

Several SARS-CoV-2 vaccines have been shown to provide protection against COVID-19 hospitalization and death. However, some evidence suggests that notable waning in effectiveness against these outcomes occurs within months of vaccination. We undertook a pooled analysis across the four nations of the UK to investigate waning in vaccine effectiveness (VE) and relative vaccine effectiveness (rVE) against severe COVID-19 outcomes.

METHODS:

We carried out a target trial design for first/second doses of ChAdOx1(Oxford-AstraZeneca) and BNT162b2 (Pfizer-BioNTech) with a composite outcome of COVID-19 hospitalization or death over the period 8 December 2020 to 30 June 2021. Exposure groups were matched by age, local authority area and propensity for vaccination. We pooled event counts across the four UK nations.

RESULTS:

For Doses 1 and 2 of ChAdOx1 and Dose 1 of BNT162b2, VE/rVE reached zero by approximately Days 60-80 and then went negative. By Day 70, VE/rVE was -25% (95% CI -80 to 14) and 10% (95% CI -32 to 39) for Doses 1 and 2 of ChAdOx1, respectively, and 42% (95% CI 9 to 64) and 53% (95% CI 26 to 70) for Doses 1 and 2 of BNT162b2, respectively. rVE for Dose 2 of BNT162b2 remained above zero throughout and reached 46% (95% CI 13 to 67) after 98 days of follow-up.

CONCLUSIONS:

We found strong evidence of waning in VE/rVE for Doses 1 and 2 of ChAdOx1, as well as Dose 1 of BNT162b2. This evidence may be used to inform policies on timings of additional doses of vaccine.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Prognostic study / Randomized controlled trials / Reviews Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Ije

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Prognostic study / Randomized controlled trials / Reviews Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Ije