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Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity.
Letsinger, Ayland C; Ward, James M; Fannin, Rick D; Mahapatra, Debabrata; Bridge, Matthew F; Sills, Robert C; Gerrish, Kevin E; Yakel, Jerrel L.
  • Letsinger AC; Neurobiology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
  • Ward JM; Bioinformatics Support Group, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
  • Fannin RD; Molecular Genomics Core Facility, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
  • Mahapatra D; Cellular and Molecular Pathogenesis Branch, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
  • Bridge MF; Inotiv, Research Triangle Park, NC, USA.
  • Sills RC; Social & Scientific Systems, Inc., a DLH Holdings Company, Durham, NC, USA.
  • Gerrish KE; Cellular and Molecular Pathogenesis Branch, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
  • Yakel JL; Molecular Genomics Core Facility, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
Sci Rep ; 13(1): 2042, 2023 02 04.
Article in English | MEDLINE | ID: covidwho-2232396
ABSTRACT
Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Nervous System Diseases Type of study: Prognostic study Topics: Long Covid Limits: Animals Language: English Journal: Sci Rep Year: 2023 Document Type: Article Affiliation country: S41598-023-29118-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Nervous System Diseases Type of study: Prognostic study Topics: Long Covid Limits: Animals Language: English Journal: Sci Rep Year: 2023 Document Type: Article Affiliation country: S41598-023-29118-6