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The therapeutic potential of non-invasive brain stimulation for the treatment of Long-COVID-related cognitive fatigue.
Linnhoff, Stefanie; Koehler, Lilli; Haghikia, Aiden; Zaehle, Tino.
  • Linnhoff S; Department of Neurology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  • Koehler L; Department of Neurology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  • Haghikia A; Department of Neurology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  • Zaehle T; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany.
Front Immunol ; 13: 935614, 2022.
Article in English | MEDLINE | ID: covidwho-2232578
ABSTRACT
Following an acute COVID-19 infection, a large number of patients experience persisting symptoms for more than four weeks, a condition now classified as Long-COVID syndrome. Interestingly, the likelihood and severity of Long-COVID symptoms do not appear to be related to the severity of the acute COVID-19 infection. Fatigue is amongst the most common and debilitating symptoms of Long-COVID. Other symptomes include dyspnoea, chest pain, olfactory disturbances, and brain fog. Fatigue is also frequently reported in many other neurological diseases, affecting a broad range of everyday activities. However, despite its clinical significance, limited progress has been made in understanding its causes and developing effective treatment options. Non-invasive brain stimulation (NIBS) methods offer the unique opportunity to modulate fatigue-related maladaptive neuronal activity. Recent data show promising results of NIBS applications over frontoparietal regions to reduce fatigue symptoms. In this current paper, we review recent data on Long-COVID and Long-COVID-related fatigue (LCOF), with a special focus on cognitive fatigue. We further present widely used NIBS methods, such as transcranial direct current stimulation, transcranial alternating current stimulation, and transcutaneous vagus nerve stimulation and propose their use as possible therapeutic strategies to alleviate individual pathomechanisms of LCOF. Since NIBS methods are safe and well-tolerated, they have the potential to enhance the quality of life in a broad group of patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Transcranial Direct Current Stimulation / COVID-19 Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.935614

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Transcranial Direct Current Stimulation / COVID-19 Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.935614