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Persistent SARS-CoV-2 infection with accumulation of mutations in a patient with poorly controlled HIV infection.
Maponga, Tongai G; Jeffries, Montenique; Tegally, Houriiyah; Sutherland, Andrew; Wilkinson, Eduan; Lessells, Richard J; Msomi, Nokukhanya; van Zyl, Gert; de Oliveira, Tulio; Preiser, Wolfgang.
  • Maponga TG; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.
  • Jeffries M; Department of Medicine, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.
  • Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
  • Sutherland A; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.
  • Wilkinson E; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.
  • Lessells RJ; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
  • Msomi N; Discipline of Virology, School of Laboratory Medicine and Medical Sciences and National Health Laboratory Service (NHLS), University of KwaZulu-Natal, Durban, South Africa.
  • van Zyl G; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.
  • de Oliveira T; National Health Laboratory Service, Tygerberg Business Unit, Cape Town, South Africa.
  • Preiser W; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Clin Infect Dis ; 2022 Jul 06.
Article in English | MEDLINE | ID: covidwho-2232964
ABSTRACT
A 22-year-old female with uncontrolled advanced HIV infection was persistently infected with SARS-CoV-2 beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6-9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Variants Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Variants Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid