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Readmissions, post-discharge mortality and sustained recovery among patients admitted to hospital with COVID-19.
Moestrup, Kasper S; Reekie, Joanne; Zucco, Adrian G; Jensen, Tomas Ø; Jensen, Jens Ulrik S; Wiese, Lothar; Ostrowski, Sisse R; Niemann, Carsten U; MacPherson, Cameron; Lundgren, Jens; Helleberg, Marie.
  • Moestrup KS; Rigshospitalet, CHIP, Centre of Excellence for Health, Immunity and Infections Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
  • Reekie J; Rigshospitalet, CHIP, Centre of Excellence for Health, Immunity and Infections Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
  • Zucco AG; Rigshospitalet, CHIP, Centre of Excellence for Health, Immunity and Infections Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
  • Jensen TØ; Rigshospitalet, CHIP, Centre of Excellence for Health, Immunity and Infections Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
  • Jensen JUS; Nordsjællands Hospital, Department of Infectious Diseases Dyrehavevej 29, 3400 Hillerød, Denmark.
  • Wiese L; Herlev and Gentofte Hospital, Department of Respiratory Diseases Gentofte Hospitalsvej 1, 2900 Hellerup, Denmark.
  • Ostrowski SR; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Niemann CU; Zealand University Hospital, Department of Infectious Diseases Sygehusvej 10, 4000 Roskilde, Denmark.
  • MacPherson C; Rigshospitalet, Department of Immunology Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
  • Lundgren J; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Helleberg M; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Clin Infect Dis ; 2022 Aug 08.
Article in English | MEDLINE | ID: covidwho-2233374
ABSTRACT

BACKGROUND:

Many interventional in-patient COVID-19 trials assess primary outcomes through day 28 post-randomization. Since a proportion of patients experience protracted disease or relapse, such follow-up period may not fully capture the course of the disease, even when randomization occurs a few days after hospitalization.

METHODS:

Among adults hospitalized with COVID-19 in Eastern Denmark from March 18, 2020 - January 12, 2021 we assessed all-cause mortality, recovery and sustained recovery 90 days after admission, and readmission and all-cause mortality 90 days after discharge. Recovery was defined as hospital discharge and sustained recovery as recovery and alive without readmissions for 14 consecutive days.

RESULTS:

Among 3,386 patients included in the study 2,796 (82.6%) reached recovery and 2,600 (77.0%) achieved sustained recovery. Of those discharged from hospital, 556 (19.9%) were readmitted, and 289 (10.3%) died. Overall, the median time to recovery was 6 days (Interquartile range (IQR), 3-10), and 19 days (IQR, 11-33) among patients in intensive care in the first two days of admission.

CONCLUSIONS:

Post-discharge readmission and mortality rates were substantial. Therefore, sustained recovery should be favored to recovery outcomes in clinical COVID-19 trials. A 28-day follow-up period may be too short the critically ill.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Prognostic study Topics: Long Covid Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Prognostic study Topics: Long Covid Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid