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Relationship Between Moderate-to-Vigorous Physical Activity and Glycemia Among Young Adults with Type 1 Diabetes and Overweight or Obesity: Results from the Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON) Study.
Muntis, Franklin R; Igudesman, Daria; Sarteau, Angelica Cristello; Thomas, Joan; Arrizon-Ruiz, Nora; Hooper, Julie; Addala, Ananta; Crandell, Jamie L; Riddell, Michael C; Maahs, David M; Pratley, Richard E; Corbin, Karen; Mayer-Davis, Elizabeth J; Zaharieva, Dessi P.
  • Muntis FR; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Igudesman D; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Sarteau AC; Advent Health Translational Research Institute, Orlando, Florida, USA.
  • Thomas J; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Arrizon-Ruiz N; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Hooper J; Division of Endocrinology, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California, USA.
  • Addala A; Division of Endocrinology, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California, USA.
  • Crandell JL; Division of Endocrinology, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California, USA.
  • Riddell MC; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Maahs DM; School of Kinesiology & Health Science, York University, Toronto, Ontario, Canada.
  • Pratley RE; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada.
  • Corbin K; Division of Endocrinology, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California, USA.
  • Mayer-Davis EJ; Stanford Diabetes Research Center, Stanford, California, USA.
  • Zaharieva DP; Advent Health Translational Research Institute, Orlando, Florida, USA.
Diabetes Technol Ther ; 24(12): 881-891, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2233573
ABSTRACT

Aims:

Using data from the ACT1ON study, we conducted secondary analyses to assess the relationship between minutes of moderate-to-vigorous physical activity (MVPA) and glycemia in adults with type 1 diabetes (T1D) and overweight or obesity. Materials and

Methods:

Participants (n = 66) with T1D provided measures of glycemia (hemoglobin A1c [HbA1c], percent of time below range <70 mg/dL, time-in-range [TIR 70-180 mg/dL], and time above range [TAR >180 mg/dL]) and self-reported physical activity (Global Physical Activity Questionnaire [GPAQ] and Previous Day Physical Activity Recalls [PDPAR]) at baseline, 3, 6, and 9 months postintervention. Wearable activity data were available for a subset of participants (n = 27). Associations were estimated using mixed effects regression models adjusted for design, demographic, clinical, and dietary covariates.

Results:

Among young adults 19-30 years of age with a baseline HbA1c of 7.9% ± 1.4% and body mass index of 30.3 (interquartile range 27.9, 33.8), greater habitual weekly MVPA minutes were associated with higher HbA1c through the GPAQ (P < 0.01) and wearable activity data (P = 0.01). We did not observe a significant association between habitual MVPA and any continuous glucose monitoring metrics. Using PDPAR data, however, we observed that greater daily MVPA minutes were associated with more TAR (P < 0.01) and reduced TIR (P < 0.01) on the day following reported physical activity.

Conclusions:

Among young adults with T1D and overweight or obesity, increased MVPA was associated with worsened glycemia. As physical activity is vital to cardiovascular health and weight management, additional research is needed to determine how to best support young adults with T1D and overweight or obesity in their efforts to increase physical activity. Clinical Trial Registration number NCT03651622.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 1 / Overweight Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Humans / Young adult Language: English Journal: Diabetes Technol Ther Journal subject: Endocrinology / Therapeutics Year: 2022 Document Type: Article Affiliation country: Dia.2022.0253

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 1 / Overweight Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Humans / Young adult Language: English Journal: Diabetes Technol Ther Journal subject: Endocrinology / Therapeutics Year: 2022 Document Type: Article Affiliation country: Dia.2022.0253