The Effects of Apium graveolens and Eucalyptus globulus in Decreasing Stress and Protecting Folliculogenesis Marker on Woman Reproductive Health during COVID-19 Pandemic
Indonesian Journal of Pharmacy
; 33(4):592-601, 2022.
Article
in English
| EMBASE | ID: covidwho-2233868
ABSTRACT
Stress during Coronavirus disease-2019 (COVID-19) pandemic affects the physiological and immunological response to women's reproductive health. Meanwhile, Apium graveolens and Eucalyptus globulus are immunomodulators related to women's reproductive health. This investigation had a goal to examine the effectiveness of A. graveolens and E. globulus towards the expression of Heat Shock Protein-70 (HSP70) as the primary biomarker of stress, Tumor Necrosis Factor-Alpha (TNF-alpha) as a pro-inflammatory protein, along with Luteinizing Hormone (LH) and Growth Differentiation Factor 9 (GDF-9) as folliculogenesis markers. An experimental randomized controlled trial was utilized by using a pre-test and post-test control group design. Sixty women, who had stress based on DASS-21 questionnaire, were divided into two groups in Nusukan Health Center, Indonesia. The intervention group was orally administered with 300 mg A. graveolens capsules and E. globulus essential oil for 14 days, while the control group was given a placebo. Blood samples and stress levels were then evaluated before and after the intervention. No significant difference was found in the stress levels of the control and treatment groups at the pre-test. Meanwhile, the intervention group had the decreased HSP70, TNF-alpha, and stress levels (p<0.001). In contrast, increased LH and GDF-9 levels were displayed in the intervention group compared to the control group (p<0.001). These findings revealed that A. graveolens supplementation and E. globulus essential oil have the ability to decrease stress and are able to protect folliculogenesis markers on women's reproductive health due to stressful conditions during pandemic COVID-19. Copyright © 2022 by Indonesian Journal of Pharmacy (IJP).
Apium graveolens; Eucalyptus globulus; folliculogenesis; immunomodulator; woman reproductive health; adult; article; blood sampling; celery; controlled study; coronavirus disease 2019; Depression, Anxiety and Stress Scale-21; drug therapy; female; gene expression; health center; human; human tissue; Indonesia; major clinical study; microcapsule; nonhuman; oral drug administration; ovary follicle development; pandemic; physiological stress; pretest posttest design; questionnaire; randomized controlled trial; reproductive health; endogenous compound; essential oil; growth differentiation factor 9; heat shock protein 70; immunomodulating agent; luteinizing hormone; placebo; tumor necrosis factor
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Observational study
/
Randomized controlled trials
Language:
English
Journal:
Indonesian Journal of Pharmacy
Year:
2022
Document Type:
Article
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