Influence of obesity on incidence of thrombosis and disease severity in patients with COVID-19: From the CLOT-COVID study.
J Cardiol
; 81(1): 105-110, 2023 01.
Article
in English
| MEDLINE | ID: covidwho-2233931
ABSTRACT
BACKGROUND:
The influence of obesity on the development of thrombosis and severity of coronavirus disease 2019 (COVID-19) remains unclear.METHOD:
The CLOT-COVID study was a retrospective multicenter cohort study enrolling 2894 consecutive hospitalized patients with COVID-19 between April 2021 and September 2021 among 16 centers in Japan. The present study consisted of 2690 patients aged over 18â¯years with available body mass index (BMI), who were divided into an obesity group (BMI ≥30) (Nâ¯=â¯457) and a non-obesity group (BMI <30) (Nâ¯=â¯2233).RESULTS:
The obesity group showed more severe status of COVID-19 at admission compared with the non-obesity group. The incidence of thrombosis was not significantly different between the groups (obesity group 2.6â¯% versus non-obesity group 1.9â¯%, pâ¯=â¯0.39), while the incidence of a composite outcome of all-cause death, or requirement of mechanical ventilation or extracorporeal membrane oxygenation during hospitalization was significantly higher in the obesity group (20.1â¯% versus 15.0â¯%, pâ¯<â¯0.01). After adjusting confounders in the multivariable logistic regression model, the risk of obesity relative to non-obesity for thrombosis was not significant (adjusted OR, 1.39; 95â¯% CI, 0.68-2.84, pâ¯=â¯0.37), while the adjusted risk of obesity relative to non-obesity for the composite outcome was significant (adjusted OR, 1.85; 95â¯% CI, 1.39-2.47, pâ¯<â¯0.001).CONCLUSIONS:
In the present large-scale observational study, obesity was not significantly associated with the development of thrombosis during hospitalization; however, it was associated with severity of COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Thrombosis
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Adult
/
Humans
/
Middle aged
Language:
English
Journal:
J Cardiol
Journal subject:
Cardiology
Year:
2023
Document Type:
Article
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