Feasibility of targeted antiviral therapy for acute respiratory viral infections in the COVID-19 pandemic.
Infektsionnye Bolezni
; 20(3):104-112, 2022.
Article
in Russian
| EMBASE | ID: covidwho-2233983
ABSTRACT
The aim of this study was to analyze the efficacy and safety of using etiotropic therapy with favipiravir and molnupiravir that can selectively bind and inhibit not only SARS-CoV-2 proteins but also other RNA-containing pathogens of acute respiratory diseases. High transmission of pathogens, the risk of becoming chronic, frequent complications, cases of co-infection with several pathogens, which can lead to a more severe course of the disease, insufficient vaccination effectiveness, all this requires additional strategies for both prevention and treatment of acute respiratory viral infections. RNA-dependent RNA polymerase (RdRp), which has no equivalent in human cells, is involved in RNA synthesis and is an excellent therapeutic target for diseases caused by RNA viruses, including SARS-CoV-2. The long process of drug development and the "reuse" of drugs approved for other indications or successfully tested in terms of safety and tolerability pose the challenge of rapid establishment of an effective drug, including for the treatment of severe cases of COVID-19. Copyright © 2022, Dynasty Publishing House.
covid-19; favipiravir; molnupiravir; RNA-dependent RNA polymerase (RdRp); SARS-CoV-2; acute respiratory tract disease; antiviral therapy; article; coinfection; comparative effectiveness; complication; controlled study; coronavirus disease 2019; drug combination; drug safety; drug therapy; drug tolerability; feasibility study; human; human cell; nonhuman; pandemic; RNA synthesis; RNA virus; Severe acute respiratory syndrome coronavirus 2; vaccination; viral respiratory tract infection; endogenous compound; RNA directed RNA polymerase
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Topics:
Vaccines
Language:
Russian
Journal:
Infektsionnye Bolezni
Year:
2022
Document Type:
Article
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