Role of Siglecs in viral infections: A double-edged sword interaction.
Mol Aspects Med
; : 101113, 2022 Aug 15.
Article
in English
| MEDLINE | ID: covidwho-2234687
ABSTRACT
Sialic-acid-binding immunoglobulin-like lectins are cell surface immune receptors known as Siglecs that play a paramount role as modulators of immunity. In recent years, research has underscored how the underlaying biology of this family of receptors influences the outcome of viral infections. While Siglecs are needed to promote effective antiviral immune responses, they can also pave the way to viral dissemination within tissues. Here, we review how recent preclinical findings focusing on the interplay between Siglecs and viruses may translate into promising broad-spectrum therapeutic interventions or key biomarkers to monitor the course of viral infections.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Prognostic study
Language:
English
Journal:
Mol Aspects Med
Year:
2022
Document Type:
Article
Affiliation country:
J.mam.2022.101113
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