Outcomes following SARS-CoV-2 infection among individuals living with and without HIV; a Danish nationwide cohort study.
AIDS
; 2022 Sep 20.
Article
in English
| MEDLINE | ID: covidwho-2234758
ABSTRACT
OBJECTIVE:
To compare the risk of a positive SARS-CoV-2 test and COVID-19 outcomes in people living with HIV (PLWH) with the general population, and estimate the association with vaccination status.DESIGN:
A nationwide, population based, matched cohort study.METHODS:
We included all Danish PLWH ≥18âyears (nâ=â5,276) and an age-and sex matched general population cohort (nâ=â42,308).We used Cox regression analyses to calculate (adjusted) incidence rate ratios [(a)IRR] and further stratified and restricted the analyses.RESULTS:
We observed no major difference in risk of first positive SARS-CoV-2 test [aIRR 0.8 (95%CI 0.8-0.9)], but a higher risk of first hospital contact with COVID-19 and hospitalization with severe COVID-19 for PLWH vs. controls [IRR 2.0; (1.6-2.5), 1.8 (1.4-2.3)]. Risk of first hospitalization decreased substantially in PLWH with calendar time [First half of year 2022 vs. 2020 IRR 0.3; (0.2-0.6)], whereas the risk compared to population controls remained almost 2-fold increased. We did not observe increased risk of death after SARS-CoV-2 infection [aIRR 0.7 (95%CI 0.3-2.0)]. Compared to PLWH who had received two vaccines PLWH who receiving a third vaccine had reduced risk of first positive SARS-CoV-2 test, death (individuals ≥60years) and hospitalization [aIRR 0.9 (0.7-1.0); 0.2 (0.1-0.7); 0.6 (0.2-1.2)].CONCLUSION:
PLWH have almost the same risk of a positive SARS-CoV-2 test as the general population. Although risk of hospital contacts and severe outcomes following SARS-CoV-2 infection is increased, the risk of death does not seem to be substantially increased. Importantly, a third vaccine is associated with reduced risk of infection, and death.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Topics:
Vaccines
Language:
English
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
2022
Document Type:
Article
Affiliation country:
QAD.0000000000003393
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