A review on synthesis of antiviral drugs, in silico studies and their toxicity

ABSTRACT

Viruses have been around us for a long period of time, they affect humans, animals and plant on cellular level by using host's body to dwell and reproduce. The spread of HIV was reported in 1981 and created a global threat to public health. In the areas of basic virology, immunology and pathogenesis of HIV/AIDS, the development of antiretroviral medicines and significant progress has been made in recent years. Majority of these antiviral compounds have the potential to be used as HIV drugs, however they are frequently accompanied with some side effects. With the emergence of the COVID-19, human race is facing a new public health crisis and repurposing of antiviral drugs to block the function of Mpro of the new corona virus has been started. This review covers the information related to the synthesis of various types of antiviral drugs and their toxicity. Some of these are used as repurposing drugs to cure patients suffering from other diseases, therefore, information for in Silico studies of antiviral drugs is incorporated. In brief, this review focused on different types of antiviral drugs, their synthesis, their repurposing role and the toxicity.