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Humoral and T-cell response 12 months after the first BNT162b2 vaccination in solid organ transplant recipients and controls: Kinetics, associated factors, and role of SARS-CoV-2 infection.
Rezahosseini, Omid; Hamm, Sebastian Rask; Heftdal, Line Dam; Pérez-Alós, Laura; Møller, Dina Leth; Perch, Michael; Madsen, Johannes Roth; Hald, Annemette; Hansen, Cecilie Bo; Armenteros, Jose Juan Almagro; Pries-Heje, Mia Marie; Hasselbalch, Rasmus Bo; Fogh, Kamille; Frikke-Schmidt, Ruth; Hilsted, Linda Maria; Sørensen, Erik; Ostrowski, Sisse Rye; Harboe, Zitta Barrella; Iversen, Kasper; Bundgaard, Henning; Sørensen, Søren Schwartz; Rasmussen, Allan; Garred, Peter; Nielsen, Susanne Dam.
  • Rezahosseini O; Viro-immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Hamm SR; Viro-immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Heftdal LD; Viro-immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Pérez-Alós L; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Møller DL; Viro-immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Perch M; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Madsen JR; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Hald A; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Hansen CB; Viro-immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Armenteros JJA; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Pries-Heje MM; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Hasselbalch RB; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Fogh K; Department of Cardiology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
  • Frikke-Schmidt R; Department of Emergency Medicine, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
  • Hilsted LM; Department of Cardiology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
  • Sørensen E; Department of Emergency Medicine, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
  • Ostrowski SR; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Harboe ZB; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Iversen K; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Bundgaard H; Department of Clinical Immunology, Section 2034, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Sørensen SS; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Rasmussen A; Department of Clinical Immunology, Section 2034, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Garred P; Viro-immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Nielsen SD; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Front Immunol ; 13: 1075423, 2022.
Article in English | MEDLINE | ID: covidwho-2234854
ABSTRACT

Introduction:

We investigated humoral and T-cell responses within 12 months after first BNT162b2 vaccine in solid organ transplant (SOT) recipients and controls who had received at least three vaccine doses. Furthermore, we compared the immune response in participants with and without previous SARS-CoV-2 infection.

Methods:

We included adult liver, lung, and kidney transplant recipients, and controls were selected from a parallel cohort of healthcare workers.

Results:

At 12th-month, the IgG geometric mean concentrations (GMCs) (P<0.001), IgA GMCs (P=0.003), and median IFN-γ (P<0.001) were lower in SOT recipients than in controls. However, in SOT recipients and controls with previous infection, the neutralizing index was 99%, and the IgG, and IgA responses were comparable. After adjustment, female-sex (aOR 3.6, P<0.009), kidney (aOR 7.0, P= 0.008) or lung transplantation (aOR 7.5, P= 0.014), and use of mycophenolate (aOR 5.2, P=0.03) were associated with low IgG non response. Age (OR1.4, P=0.038), time from transplantation to first vaccine (OR 0.45, P<0.035), and previous SARS-CoV-2 infection (OR 0.14, P<0.001), were associated with low IgA non response. Diabetes (OR2.4, P=0.044) was associated with T-cell non response.

Conclusion:

In conclusion, humoral and T-cell responses were inferior in SOT recipients without previous SARS-CoV-2 infection but comparable to controls in SOT recipients with previous infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / Lung Transplantation / COVID-19 / BNT162 Vaccine Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Female / Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.1075423

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / Lung Transplantation / COVID-19 / BNT162 Vaccine Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Female / Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.1075423