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Engineering organ-on-a-chip systems to model viral infections.
Shahabipour, Fahimeh; Satta, Sandro; Mahmoodi, Mahboobeh; Sun, Argus; de Barros, Natan Roberto; Li, Song; Hsiai, Tzung K; Ashammakhi, Nureddin.
  • Shahabipour F; Shahid Beheshti University of Medical Science, Skin Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran, Tehran, 1316943551, Iran (the Islamic Republic of).
  • Satta S; Department of Medicine, University of California Los Angeles, Department of Medicine, School of Medicine, University of California, Los Angeles, California, USA, Los Angeles, 90095, UNITED STATES.
  • Mahmoodi M; UCLA, Department of Bioengineering, School of Engineering, University of California, Los Angeles, California, USA, Los Angeles, California, 90095, UNITED STATES.
  • Sun A; Department of Bioengineering, University of California Los Angeles, Department of Bioengineering, School of Engineering, University of California, Los Angeles, California, USA, Los Angeles, 90095, UNITED STATES.
  • de Barros NR; University of California, Department of Bioengineering, School of Engineering, University of California, Los Angeles, California, USA, Los Angeles, CA 90095, UNITED STATES.
  • Li S; Department of Bioengineering, University of California Los Angeles, 5121 Eng V, Los Angeles, California, 90095, UNITED STATES.
  • Hsiai TK; Director UCLA Cardiovascular Eng Reserch, University of California Los Angeles, Molecular, Cellular, and Integrated Biology, Division of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, California, USA, Los Angeles, CA 90095, UNITED STATES.
  • Ashammakhi N; Department of Bioengineering, University of California Los Angeles, Department of Bioengineering, School of Engineering, University of California, Los Angeles, California, USA, Los Angeles, 90095, UNITED STATES.
Biofabrication ; 2022 Apr 07.
Article in English | MEDLINE | ID: covidwho-2235454
ABSTRACT
Infectious diseases remain a public healthcare concern worldwide. Amidst the pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, increasing resources have been diverted to investigate the therapeutics targeting COVID-19 Spike glycoprotein and to develop various classes of vaccines. Most of the current investigations employ two-dimensional (2D) cell culture and animal models. However, 2D culture negates the multicellular interactions and 3D microenvironment, and animal models cannot mimic human physiology because of interspecies differences. On the other hand, organ-on-a-chip (OoC) research devices introduce a game-changer to model viral infections in human tissues, facilitating high-throughput screening of antiviral therapeutics. In this context, this review provides an overview of the in vitro OoC-based modeling of viral infection, highlighting the strengths and challenges for the future directions.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal subject: Biotechnology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal subject: Biotechnology Year: 2022 Document Type: Article