Steroids - Exploitation
International Journal of Applied Pharmaceutics
; 15(1):106.0, 2023.
Article
in English
| EMBASE | ID: covidwho-2236243
ABSTRACT
Corticosteroids, more specifically glucocorticoids are one of the most prescribed drugs. Corticosteroids are adrenal hormones that serve significant physiologic activities such as modulating glucose metabolism, protein catabolism, calcium metabolism, bone turnover control, immunosuppression, and down-regulation of inflammatory cascade. Corticosteroids are regarded life-saving due to their various effects and have been used therapeutically to treat broad range of auto-immune, rheumatologic, inflammatory, neoplastic, and viral illnesses.However, the therapeutic benefits of glucocorticoids are restricted by the adverse effects. The most serious side effects of corticosteroids are associated with the use of higher doses for longer periods and OTC availability in specific pharmacies, which leads to dependency, as well as its usage in mild and moderate server instances, which is contrary to guidelines. In the recent times the use of corticosteroids has been multiplied with the emergence of the Covid -19 pandemic. WHO and the standard guidelines has recommended the usage of corticosteroids in critically ill covid-19 patients but their usage in mild and moderate cases caused more harm than benefit. This illicit usage has resulted in the development of opportunistic fungal illnesses such as mucormycosis, posing an extra risk to patients in terms of quality of life and finances. Other adverse effects of systemic corticosteroids include morphological changes, increased blood sugar levels, delayed wound healing, infections, decreased bone density, truncal obesity, cataracts, glaucoma, blood pressure abnormalities, and muscle fibre atrophy.In this review we want to discuss the significance and detrimental effects of corticosteroids emphasizing on the recent times i.e., COVID-19.
Adverse effects; Anti-inflammatory; Corticosteroids; covid-19; Glucocorticoids; abdominal obesity; adult; blood pressure; bone density; bone turnover; calcium metabolism; cataract; conference abstract; coronavirus disease 2019; critically ill patient; down regulation; drug megadose; drug therapy; finance; glaucoma; glucose blood level; glucose metabolism; human; immunosuppressive treatment; mucormycosis; muscle atrophy; pandemic; pharmacy (shop); practice guideline; protein degradation; quality of life; risk assessment; surgery; virus infection; wound healing impairment; corticosteroid; glucocorticoid; hormone
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Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
International Journal of Applied Pharmaceutics
Year:
2023
Document Type:
Article
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