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Utilization of antidepressants, anxiolytics, and hypnotics during the COVID-19 pandemic in Scandinavia.
Tiger, Mikael; Wesselhoeft, Rikke; Karlsson, Pär; Handal, Marte; Bliddal, Mette; Cesta, Carolyn E; Skurtveit, Svetlana; Reutfors, Johan.
  • Tiger M; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Sweden. Electronic address: mikael.tiger@ki.se.
  • Wesselhoeft R; Clinical Pharmacology, Pharmacy and Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark; Child and Adolescent Mental Health Odense, Mental Health Services in the Region of Southern Denmark.
  • Karlsson P; Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden.
  • Handal M; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway; Norwegian Centre for Addiction Research (SERAF), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Bliddal M; Clinical Pharmacology, Pharmacy and Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark; Research Unit OPEN, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • Cesta CE; Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden.
  • Skurtveit S; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway; Norwegian Centre for Addiction Research (SERAF), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Reutfors J; Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden.
J Affect Disord ; 323: 292-298, 2022 Nov 25.
Article in English | MEDLINE | ID: covidwho-2236292
ABSTRACT

OBJECTIVE:

To study patterns of antidepressant, anxiolytic, and hypnotic drug utilization in Denmark, Norway, and Sweden during the first year of the COVID-19 pandemic.

METHODS:

The monthly observed number of prescription fills of antidepressants, benzodiazepines and benzodiazepine-related hypnotics (BZ), and other anxiolytics and hypnotics (OAH) per population in 2020 were compared with predicted numbers based on analysis of covariance of prescription fills during 2015-2019.

RESULTS:

In March 2020, there was an increased number of prescription fills for antidepressants, anxiolytics, and hypnotics in youths and adults aged 20-59 years in Denmark, Norway, and Sweden. Antidepressant prescription fills increased between 13.5 % and 31.3 % at the end of 2020 in all age groups in Denmark and 17.4 % in youths in Norway. BZ drug prescription fills increased by 20.8 % at the end of 2020 in the 20-59 year age group in Denmark and decreased by 16.7 % in youths in Sweden. A general increase of prescription fills of OAH at the end of 2020 was observed in all countries (range 24.0-80.0 % in Denmark, 11.5-30.8 % in Norway, and 9.1-12.1 % in Sweden). Increases of prescription fills of OAH occurred earlier in Denmark.

LIMITATIONS:

Aggregated data with lack of information on indications.

CONCLUSIONS:

Peaks of utilization of antidepressants, anxiolytics, and hypnotics observed in March 2020 may reflect medication stock piling. Increased antidepressant drug utilization in Denmark and in Norwegian youths together with the general increase in OAH utilization in the Scandinavian countries in late 2020 may indicate an increase of symptoms of depression and anxiety, as well as disturbed sleep.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Language: English Journal: J Affect Disord Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Language: English Journal: J Affect Disord Year: 2022 Document Type: Article