A rare case of pulmonary benign metastasising leiomyomatosis in a woman with a previous history of hysterectomy for uterine fibroids.
Clin Med (Lond)
; 23(1): 78-80, 2023 01.
Article
in English
| MEDLINE | ID: covidwho-2236308
ABSTRACT
Benign metastasising leiomyomatosis (BML) is a rare disease, predominantly seen in premenopausal women. It poses a diagnostic dilemma and can be misdiagnosed as malignancy. Here we present a case of 41-year-old woman with a previous history of hysterectomy 10 years ago for multiple fibroids. She presented with shortness of breath and chest discomfort. Chest X-ray showed pulmonary infiltrates. She was diagnosed with sarcoidosis and treated with steroids without any improvement. Further investigations including CT scan and bronchoscopy and lavage failed to confirm a diagnosis. Subsequently she underwent video-assisted thoracoscopic surgery and histopathology revealed leiomyomatosis (so-called leiomyomatous hamartomas/benign metastasising leiomyomatosis). Oestrogen and progesterone receptors showed diffuse and strong nuclear staining. The patient was commenced on tamoxifen and a repeat chest X-ray in 8 weeks showed significant improvement. In women of reproductive age with previous hysterectomy and multiple lung nodules on imaging, the diagnosis of BML should be taken into consideration.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Uterine Neoplasms
/
Leiomyomatosis
/
Multiple Pulmonary Nodules
/
Lung Neoplasms
Type of study:
Case report
/
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Clin Med (Lond)
Year:
2023
Document Type:
Article
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