Modeling and multi-objective optimal control of reaction-diffusion COVID-19 system due to vaccination and patient isolation.
Appl Math Model
; 118: 556-591, 2023 Jun.
Article
in English
| MEDLINE | ID: covidwho-2236430
ABSTRACT
In this paper, a reaction-diffusion COVID-19 model is proposed to explore how vaccination-isolation strategies affect the development of the epidemic. First, the basic dynamical properties of the system are explored. Then, the system's asymptotic distributions of endemic equilibrium under different conditions are studied. Further, the global sensitivity analysis of R 0 is implemented with the aim of determining the sensitivity for these parameters. In addition, the optimal vaccination-isolation strategy based on the optimal path is proposed. Meantime, social cost C ( m , σ ) , social benefit B ( m , σ ) , threshold R 0 ( m , σ ) three objective optimization problem based on vaccination-isolation strategy is explored, and the maximum social cost ( M S C ) and maximum social benefit ( M S B ) are obtained. Finally, the instance prediction of the Lhasa epidemic in China on August 7, 2022, is made by using the piecewise infection rates ß 1 ( t ) , ß 2 ( t ) , and some key indicators are obtained as follows (1) The basic reproduction numbers of each stage in Lhasa, China are R 0 ( 1 8 ) = 0.4678 , R 0 ( 9 20 ) = 2.7655 , R 0 ( 21 30 ) = 0.3810 and R 0 ( 31 100 ) = 0.7819 ; (2) The daily new cases of this epidemic will peak at 43 on the 20th day (August 26, 2022); (3) The cumulative cases in Lhasa, China will reach about 640 and be cleared about the 80th day (October 28, 2022). Our research will contribute to winning the war on epidemic prevention and control.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
/
Prognostic study
Topics:
Vaccines
/
Variants
Language:
English
Journal:
Appl Math Model
Year:
2023
Document Type:
Article
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