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Influenza vaccine and subsequent development of zoster.
Wei, Kai-Che; Chang, Yu-Chia; Huang, Yu-Tung.
  • Wei KC; Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
  • Chang YC; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Huang YT; Department of Long-Term Care, College of Health and Nursing, National Quemoy University, Kinmen County, Taiwan.
Influenza Other Respir Viruses ; 2022 Sep 17.
Article in English | MEDLINE | ID: covidwho-2236910
ABSTRACT

BACKGROUND:

Herpes zoster (HZ), which is caused by reactivation of the latent varicella zoster virus, was not listed as a side effect of any vaccines until the introduction of coronavirus disease 2019 (COVID-19) vaccine. This study used a nationwide population database to examine whether the HZ risk is increased after receiving the influenza vaccination.

METHODS:

This population-based retrospective self-controlled case series evaluated the association between influenza vaccine exposure and HZ risk. Data were collected from Taiwan's National Health Insurance Research Database between 2015 and 2017. Patients with HZ diagnosed within 6 months before and after receiving the influenza vaccination were included. After receiving the influenza vaccine, the first 15 and 30 days were defined as risk intervals, while the other periods were defined as control intervals. Poisson regression was used to compare the incidence rate ratio (IRR) for HZ during the risk interval vs. the control interval.

RESULTS:

In total, 13,728 patients were diagnosed with HZ before and after receiving the influenza vaccine. The IRR for days 1-15 was significantly higher (IRR = 1.11; 95% confidence interval [CI], 1.02-1.20), but insignificant for days 1-30 (IRR = 1.04; 95% CI, 0.98-1.10). In a subgroup analysis, the IRRs were significantly higher in participants, including 50-64 years old (1.16; 95% CI, 1.02-1.33), males (1.14; 95% CI, 1.01-1.28), and healthier individuals (i.e., no history of cancer or autoimmune diseases).

CONCLUSIONS:

There was a slight increase in risk of HZ in people receiving influenza vaccine in the first 1-15 days after vaccination.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: Irv.13055

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: Irv.13055