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Recombinant vesicular stomatitis virus-vectored vaccine induces long lasting immunity against Nipah virus disease.
Woolsey, Courtney; Borisevich, Viktoriya; Fears, Alyssa C; Agans, Krystle N; Deer, Daniel J; Prasad, Abhishek N; O'Toole, Rachel; Foster, Stephanie L; Dobias, Natalie S; Geisbert, Joan B; Fenton, Karla A; Cross, Robert W; Geisbert, Thomas.
  • Woolsey C; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, United States of America.
  • Borisevich V; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, United States of America.
  • Fears AC; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, United States of America.
  • Agans KN; Department of Microbiology and Immunology, University of Texas Medical Branch at Galvetson, Galveston, United States of America.
  • Deer DJ; Department of Microbiology and Immunology, University of Texas Medical Branch at Galvetson, Galveston, United States of America.
  • Prasad AN; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, United States of America.
  • O'Toole R; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, United States of America.
  • Foster SL; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, United States of America.
  • Dobias NS; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, United States of America.
  • Geisbert JB; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, United States of America.
  • Fenton KA; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, United States of America.
  • Cross RW; Department of Microbiology and Immunology, University of Texas Medical Branch at Galvetson, Galveston, United States of America.
  • Geisbert T; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, United States of America.
J Clin Invest ; 2022 Nov 29.
Article in English | MEDLINE | ID: covidwho-2237068
ABSTRACT
The emergence of the novel henipavirus, Langya virus, received global attention earlier this month after the virus sickened over three dozen people in China. There is heightened concern henipaviruses as respiratory pathogens could spark another pandemic, most notably the deadly Nipah virus (NiV). NiV causes near annual outbreaks in Bangladesh and India and induces a highly fatal respiratory disease and encephalitis in humans. No licensed countermeasures against this pathogen exist. An ideal NiV vaccine would confer both fast-acting and long-lived protection. Recently, we reported the generation of a recombinant vesicular stomatitis virus (rVSV)-based vaccine expressing the NiV glycoprotein (rVSV-ΔG-NiVBG) that protected 100% of nonhuman primates from NiV-associated lethality within a week. Here, to evaluate the durability of rVSV-ΔG-NiVBG, we vaccinated African green monkeys (AGMs) one year prior to challenge with a uniformly lethal dose of NiV. The rVSV-ΔG-NiVBG vaccine induced stable and robust humoral responses, whereas cellular responses were modest. All immunized AGMs (whether receiving a single dose or prime-boosted) survived with no detectable clinical signs or NiV replication. Transcriptomic analyses indicated adaptive immune signatures correlated with vaccine-mediated protection. While vaccines for certain respiratory infections (e.g., COVID-19) have yet to provide durable protection, our results suggest rVSV-ΔG-NiVBG elicits long-lasting immunity.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: JCI164946

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: JCI164946