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The Synthesis of Urolithins and Their Derivatives and the Modes of Antitumor Action.
Xu, Xiangrong; Liu, Zhuanhong; Yao, Lei.
  • Xu X; School of Pharmacy, Yantai University, Yantai 264005, China.
  • Liu Z; School of Pharmacy, Yantai University, Yantai 264005, China.
  • Yao L; School of Pharmacy, Yantai University, Yantai 264005, China.
Mini Rev Med Chem ; 2022 May 16.
Article in English | MEDLINE | ID: covidwho-2237166
ABSTRACT
Urolithins are microbial metabolites derived from berries and pomegranate fruits, which display anti-inflammatory, anti-oxidative, and anti-aging activities. There are eight natural urolithins (urolithin A-E, M5, M6 and M7) isolated by now. Structurally, urolithins are phenolic compounds and belong to 6H-dibenzo[b,d]pyran-6-one. They have drawn considerable attention because of their vast range of biological activities and health benefits. Recent studies also suggest that they possess anti-SARS-CoV-2 and anticancer effects. In this article, the recent advances on the synthesis of urolithins and their derivatives from 2015 to 2021 are reviewed. To improve or overcome the solubility and metabolism stability issues, the modifications of urolithins are mainly centered on the hydroxy group and lactone group, and some compounds are showing promising results and potential for further study. The possible modes of antitumor action of urolithin are also discussed. Several signaling pathways, including PI3K-Akt, Wnt/ß-catenin pathways, and multiple receptors (aryl hydrocarbon receptor, estrogen and androgen receptors) and enzymes (tyrosinase and lactate dehydrogenase) are involved in the antitumor activity of urolithins.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: 1389557522666220516125500

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: 1389557522666220516125500