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Genetic predisposition to blood cell indices in relation to severe COVID-19.
Yao, Yao; Song, Hongfei; Zhang, Fanshuang; Liu, Jibin; Wang, Dong; Feng, Quansheng; Rao, Shuquan; Jiang, Cen.
  • Yao Y; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
  • Song H; Traditional Chinese Medicine and Inflammation Regulation Research Group, School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China.
  • Zhang F; Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.
  • Liu J; Traditional Chinese Medicine and Inflammation Regulation Research Group, School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China.
  • Wang D; Traditional Chinese Medicine and Inflammation Regulation Research Group, School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China.
  • Feng Q; Traditional Chinese Medicine and Inflammation Regulation Research Group, School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China.
  • Rao S; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
  • Jiang C; Traditional Chinese Medicine and Inflammation Regulation Research Group, School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China.
J Med Virol ; 2022 Aug 29.
Article in English | MEDLINE | ID: covidwho-2237255
ABSTRACT
Despite considerable variation in disease manifestations observed among coronavirus disease 2019 (COVID-19) patients infected with severe acute respiratory syndrome coronavirus 2, the risk factors predicting disease severity remain elusive. Recent studies suggest that peripheral blood cells play a pivotal role in COVID-19 pathogenesis. Here, we applied two-sample Mendelian randomization (MR) analyses to evaluate the potential causal contributions of blood cell indices variation to COVID-19 severity, using single-nucleotide polymorphisms (SNPs) as instrumental variables for 17 indices from the UK Biobank and INTERVAL genome-wide association studies (N = 173 480). Data on the associations between the SNPs and very severe respiratory confirmed COVID-19 were obtained from the COVID-19 host genetics initiative (N = 8779/1 001 875). We observed significant negative association between hematocrit (HCT; odds ratio, OR = 0.775, 95% confidence interval, CI = 0.635-0.915, p = 3.48E-04) or red blood cell count (OR = 0.830, 95% CI = 0.728-0.932, p = 2.19E-03) and very severe respiratory confirmed COVID-19, as well as nominal negative association of hemoglobin concentration (OR = 0.808, 95% CI = 0.673-0.943, p = 3.95E-03) with very severe respiratory confirmed COVID-19 (no effect survived multiple correction). In conclusion, the MR study supports a protective effect of high HCT and red blood cell count from very severe respiratory confirmed COVID-19, suggesting potential strategies to ameliorate/treat clinical conditions in very severe respiratory confirmed COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jmv.28104

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jmv.28104