Melatonin levels are low in COVID-19 positive patients and these levels are associated with depression, death anxiety and insomnia.
Scand J Clin Lab Invest
; 83(2): 86-94, 2023 04.
Article
in English
| MEDLINE | ID: covidwho-2237317
ABSTRACT
In this study, we aimed to measure the melatonin levels in COVID-19 positive patients and to investigate the relationship of these levels with depression, death anxiety and insomnia. COVID-19 positive pneumonia group, COVID-19 negative pneumonia group and healthy control groups were included in the study. Melatonin ELISA kit was used. Blood samples were taken at 2300 h (h), 0200 h and 0600 h. Beck Depression Inventory (BDI), Templer Death Anxiety Scale (TDAS), Insomnia Severity Index (ISI) were employed to collect data from the participants. The melatonin levels of COVID-19 positive patients at 2300 h were lower than the control group. In addition, and the melatonin levels of COVID-19 positive patients at 0200 h and at 0600 h were lower than both the COVID-19 negative patient group and the control group. It was observed that the peak melatonin concentration of COVID-19 positive patients occurred at 0600 h. BDI, TDAS and ISI scores of COVID-19 positive patients were higher than other groups. There was a negative correlation between BDI, TDAS, ISI scores of COVID-19 positive patients and their melatonin levels. The correlation between all scale scores and melatonin levels was higher at 0200 h. Adding melatonin to the treatment of COVID-19 positive patients may be beneficial for these patients experiencing high levels of depression, anxiety and insomnia.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Sleep Initiation and Maintenance Disorders
/
Melatonin
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Scand J Clin Lab Invest
Year:
2023
Document Type:
Article
Affiliation country:
00365513.2023.2175236
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