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Morphological and functional findings in COVID-19 lung disease as compared to Pneumonia, ARDS, and High-Altitude Pulmonary Edema.
Zubieta-Calleja, Gustavo R; Zubieta-DeUrioste, Natalia; de Jesús Montelongo, de Jesus MontelongoFelipe; Sanchez, Manuel Gabriel Romo; Campoverdi, Aurio Fajardo; Rocco, Patricia Rieken Macedo; Battaglini, Denise; Ball, Lorenzo; Pelosi, Paolo.
  • Zubieta-Calleja GR; High Altitude Pulmonary and Pathology Institute (HAPPI - IPPA), La Paz, Bolivia.
  • Zubieta-DeUrioste N; High Altitude Pulmonary and Pathology Institute (HAPPI - IPPA), La Paz, Bolivia.
  • de Jesús Montelongo JM; Hospital General de Ecatepec "Las Américas", ISEM, Mexico.
  • Sanchez MGR; Hospital General de Ecatepec "Las Américas", ISEM, Mexico.
  • Campoverdi AF; Critical Care Unit, Viña del Mar, Chile.
  • Rocco PRM; Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; COVID-19 Virus Network, Ministry of Science, Technology, and Innovation, Brasilia, Brazil.
  • Battaglini D; Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy. Electronic address: battaglini.denise@gmail.com.
  • Ball L; Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy; Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
  • Pelosi P; Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy; Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
Respir Physiol Neurobiol ; : 104000, 2022 Nov 29.
Article in English | MEDLINE | ID: covidwho-2237682
ABSTRACT
Coronavirus disease-2019 (COVID-19) may severely affect respiratory function and evolve to life-threatening hypoxia. The clinical experience led to the implementation of standardized protocols assuming similarity to severe acute respiratory syndrome (SARS-CoV-2). Understanding the histopathological and functional patterns is essential to better understand the pathophysiology of COVID-19 and then develop new therapeutic strategies. Epithelial and endothelial cell damage can result from the virus attack, thus leading to immune-mediated response. Pulmonary histopathological findings show the presence of Mallory bodies, alveolar coating cells with nuclear atypia, reactive pneumocytes, reparative fibrosis, intra-alveolar hemorrhage, moderate inflammatory infiltrates, micro-abscesses, microthrombus, hyaline membrane fragments, and emphysema-like lung areas. COVID-19 patients may present different respiratory stages from silent to critical hypoxemia, are associated with the degree of pulmonary parenchymal involvement, thus yielding alteration of ventilation and perfusion relationships. This review aims to discuss the morphological (histopathological and radiological) and functional findings of COVID-19 compared to acute interstitial pneumonia, acute respiratory distress syndrome (ARDS), and high-altitude pulmonary edema (HAPE), four entities that share common clinical traits, but have peculiar pathophysiological features with potential implications to their clinical management.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Respir Physiol Neurobiol Year: 2022 Document Type: Article Affiliation country: J.resp.2022.104000

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Respir Physiol Neurobiol Year: 2022 Document Type: Article Affiliation country: J.resp.2022.104000