SARS Cov-2 infection in a pregnant patient with Fabry's disease type I
Revista de Nefrologia, Dialisis y Trasplante
; 42(4):325-329, 2022.
Article
in Spanish
| EMBASE | ID: covidwho-2238898
ABSTRACT
Aqui va el texto que falta Fabry's disease (EF) [OMIM 301500] is a lysosomal deposit disease, linked to an X chromosome, caused by the deficiency of the α-galactosidase enzyme (α gal), which generates the progressive accumulation of globotriaosylceramide (GB3)(2) mainly in vascular endothelium, producing endotheliopathy with important systemic manifestations(3). The factors for critical disease by SARSCov-2, identified in the general population, overlap with symptoms seen in adult patients with EF. Objective:
Report the case of a patient with EF type I who presented infection by the SARSCov-2 virus during the third pregnancy quarter.Results:
Pregnancy evolved at term without complications;the resolution was segmental cesarean section due to dilatation dystocia, obtaining a single male product in good general conditions, without exacerbation of the symptoms of the EF;The bimonthly trend scheme was maintained with home infusion Agalsidase B.Conclusion:
Pregnancy can evolve without complications in patients with EF;that enzymatic replacement therapy is safe during it, and despite the vulnerability of EF patients, SARS COV-2 infection can evolve in a benign way.
agalsidase beta; alpha galactosidase; globotriaosylceramide; article; cesarean section; coronavirus disease 2019; dilatation; disease exacerbation; dystocia; endothelial dysfunction; enzyme replacement; Fabry disease; female; human; pregnancy; pregnant woman; Severe acute respiratory syndrome coronavirus 2; vascular endothelium; vulnerability
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
Spanish
Journal:
Revista de Nefrologia, Dialisis y Trasplante
Year:
2022
Document Type:
Article
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