Enveloped Viruses: Pathogenetic Targets for Cyanobacterial Lectins
Antibiotiki i Khimioterapiya
; 67(45082):39-60, 2022.
Article
in Russian
| EMBASE | ID: covidwho-2239152
ABSTRACT
Lectins are a group of highly specific carbohydrate-binding proteins with a wide spectrum of action, involved in the so-called «first line» of body defense. These unique biomolecules show high specificity for various mono- and oligosaccharides, primarily for viral and bacterial glycoconjugates. Cyanobacteria lectins are effective against enveloped viruses and are an appealing alternative to existing synthetic drugs. Virtually complete absence of resistance formation in viruses to these compounds is known. The purpose of this review is to analyze, summarize, and discuss the results of experimental studies in vivo and in vitro, illustrating the mechanisms of action and antiviral effects of lectins obtained from cyanobacteria in relation to the most dangerous and socially significant viruses SARS-Cov-2, HIV, Ebola viruses, influenza, and hepatitis C. In addition, the article outlines some of the challenges that must be overcome in order to obtain effective antiviral drugs in the future.
animal experiment; animal model; antiviral activity; cyanobacterium; Ebolavirus; experimental study; hepatitis C; Human immunodeficiency virus; in vitro study; in vivo study; influenza; nonhuman; protein function; review; Severe acute respiratory syndrome coronavirus 2; antivirus agent; endogenous compound; lectin
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
Russian
Journal:
Antibiotiki i Khimioterapiya
Year:
2022
Document Type:
Article
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