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Monocyte Distribution Width (MDW) as a biomarker of sepsis: An evidenced-based laboratory medicine approach.
Ciaccio, Anna Maria; Agnello, Luisa; Sasso, Bruna Lo; Giglio, Rosaria Vincenza; Iacona, Alessandro; Gambino, Caterina Maria; Scazzone, Concetta; Tuttolomondo, Antonino; Ciaccio, Marcello.
  • Ciaccio AM; Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, "G. D'Alessandro", University of Palermo, 90127 Palermo, Italy.
  • Agnello L; Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, Italy.
  • Sasso BL; Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, Italy; Department of Laboratory Medicine, University Hospital "P. Giaccone", 90127 Palermo, Italy
  • Giglio RV; Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, Italy; Department of Laboratory Medicine, University Hospital "P. Giaccone", 90127 Palermo, Italy
  • Iacona A; Department of Laboratory Medicine, University Hospital "P. Giaccone", 90127 Palermo, Italy.
  • Gambino CM; Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, Italy; Department of Laboratory Medicine, University Hospital "P. Giaccone", 90127 Palermo, Italy
  • Scazzone C; Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, Italy.
  • Tuttolomondo A; Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, "G. D'Alessandro", University of Palermo, 90127 Palermo, Italy.
  • Ciaccio M; Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, Italy; Department of Laboratory Medicine, University Hospital "P. Giaccone", 90127 Palermo, Italy
Clin Chim Acta ; 540: 117214, 2023 Feb 01.
Article in English | MEDLINE | ID: covidwho-2239827
ABSTRACT
Monocyte Distribution Width (MDW) is a new generation cell blood count parameter providing a measure of monocyte anisocytosis. In the last decades, it has emerged as a reliable biomarker of sepsis in the acute setting, especially emergency department, and intensive care unit. MDW has several advantages over commonly used sepsis biomarkers, including low-cost, ease and speed of measurement. The clinical usefulness of MDW has been established in several studies and some clinical laboratory medicines have already implemented it in their routine. In this article, we describe the analytical and clinical features of MDW to guide its appropriate use in clinical practice by integrating the research evidence with real-world laboratory experience. The proper use of a biomarker is critical for improving patients' care and outcome as well as ensuring healthcare quality.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Monocytes / Sepsis Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Clin Chim Acta Year: 2023 Document Type: Article Affiliation country: J.cca.2022.117214

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Monocytes / Sepsis Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Clin Chim Acta Year: 2023 Document Type: Article Affiliation country: J.cca.2022.117214