Screening rate for Hepatitis D in Hepatitis B patients: Tips and tricks
Digestive and Liver Disease
; 55:S43, 2023.
Article
in English
| EMBASE | ID: covidwho-2239950
ABSTRACT
Introduction:
Hepatitis B virus (HBV) and its satellite virus hepatitis D (HDV) are common worldwide hepatotrophic infections responsible for cirrhosis and hepatocellular carcinoma. EASL practice guidelines recommend HDV screening in all Hep B patients. Novel therapies for Hep D are promising.Aim:
To determine screening rates for HDV in HBV patients referred to our Laboratory of Hub Hospital Pordenone (Friuli Venezia Giulia).Methods:
We retrospectively considered HBsAg positive results from 01.01.2018 to 31.12.2021. Using an extended database to 30.11.2022, we considered, among those were HBsAg positive, anti-HDV results and if we detected positivity for anti-HDV, we checked if HDV-RNA was performed.Results:
931 patients (55% non-Italian native) positive for hepatitis B surface antigen were studied with a majority male patients (65%). Of 931, 470 (50%) Hep B patients were screened for Hep D and 13 (1.4%) (9 non-Italian native) were positive for anti-HDV. Of 13, 6 were positive for serum HDV-RNA;3 subjects were negative for HDV-RNA while 4 patients did not perform HDV-RNA. 10 Hep-B patients (1%) negative for anti-HDV at first time were re-tested for anti-HDV more than once. Comparing 2018-2019 vs 2020-2021, screening rate for Hep D decreased from 56% to 40%.Conclusions:
Despite current HDV guidelines, in our Hospital HDV screening is suboptimal and it is actually declining. In fact COVID-19 has caused the slowing down of hepatitis testing program. Therefore we suggest 1) anti-HDV simplified and automated reflex testing algorithms in Hep B patients for an early diagnosis and linkage to care of HDV infection;2) enhancement of molecular biology for HDV-RNA assay in our Italian Labs;3) repeating more than once anti-HDV especially in high-risk HBV patients. Furthermore, we need to be careful for Hep B vaccine to reduce Hep D screening and disease burden.
hepatitis B surface antigen; vaccine; adult; algorithm; conference abstract; controlled study; coronavirus disease 2019; disease burden; early diagnosis; Friuli Venezia Giulia; hepatitis B; Hepatitis B virus; Hepatitis delta virus; human; human tissue; major clinical study; male; molecular biology; nonhuman; practice guideline; reflex; retrospective study; risk assessment; RNA analysis
Full text:
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Digestive and Liver Disease
Year:
2023
Document Type:
Article
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