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Evolution of increased positive charge on the SARS-CoV-2 spike protein may be adaptation to human transmission.
Cotten, Matthew; Phan, My V T.
  • Cotten M; Medical Research Council-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow G61 1QH, Scotland, UK.
  • Phan MVT; UK Medical Research Council-Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Plot 51- 59 Nakiwogo Road, P.O Box 49, Entebbe, Uganda, UK.
iScience ; 26(3): 106230, 2023 Mar 17.
Article in English | MEDLINE | ID: covidwho-2239960
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and infect individuals. The exterior surface of the SARS-CoV-2 virion is dominated by the spike protein, and the current work examined spike protein biochemical features that have changed during the 3 years in which SARS-CoV-2 has infected humans. Our analysis identified a striking change in spike protein charge, from -8.3 in the original Lineage A and B viruses to -1.26 in most of the current Omicron viruses. We conclude that in addition to immune selection pressure, the evolution of SARS-CoV-2 has also altered viral spike protein biochemical properties, which may influence virion survival and promote transmission. Future vaccine and therapeutic development should also exploit and target these biochemical properties.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines / Variants Language: English Journal: IScience Year: 2023 Document Type: Article Affiliation country: J.isci.2023.106230

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines / Variants Language: English Journal: IScience Year: 2023 Document Type: Article Affiliation country: J.isci.2023.106230