Comparative Study on the Role of Serum Levels of Interleukin6 and Interleukin-8 in Predicting the Severity of COVID-19 and Prognosis in Patients Admitted to Ghaemshahr Razi Hospital
Journal of Mazandaran University of Medical Sciences
; 32(217):124-134, 2023.
Article
in Persian
| EMBASE | ID: covidwho-2240114
ABSTRACT
Background and purpose:
The Coronavirus Disease 2019 (COVID-19) pandemic, caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in a worldwide emergency. Various studies show conflicting and diverse results on the role of inflammatory cytokines in predicting the severity and prognosis in patients with COVID-19. The aim of this study was to compare the serum levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) in predicting the severity of COVID-19 and prognosis in patients admitted to Qaemshahr Razi Hospital. Materials andmethods:
In this cross-sectional prospective study, the serum levels of interleukin 8 and 6 were measured in 51 patients with COVID-19 and compared with 25 healthy individuals in Qaemshahr Razi Hospital, 2021. ELISA method was used to measure these cytokines and data analysis was performed in SPSS V25.Results:
The serum levels of IL6 and IL8 in the patient group were about 4 times and 6 times higher than those of the control group, respectively. Average levels of IL-6 (P=0.004) and IL-8 (P<0.001) were significantly higher in patients with severe COVID-19 compared to moderate form and control group. There was no correlation between the duration of hospitalization and the level of IL-6 (P=0.1), while there was a significant correlation between the length of hospital stay and the level of IL-8 (P=0.012).Conclusion:
IL-6 and IL-8 serum levels in patients with COVID-19 can be helpful in predicting the severity of disease and prognosis of patients.
adult; article; comparative study; controlled study; coronavirus disease 2019; data analysis software; enzyme linked immunosorbent assay; female; gene expression; hospitalization; human; human tissue; major clinical study; male; prognosis; prospective study; protein blood level; protein expression; protein function; cytokine; endogenous compound; interleukin 6; interleukin 8
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Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
Persian
Journal:
Journal of Mazandaran University of Medical Sciences
Year:
2023
Document Type:
Article
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