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Delta-Omicron recombinant escapes therapeutic antibody neutralization.
Duerr, Ralf; Zhou, Hao; Tada, Takuya; Dimartino, Dacia; Marier, Christian; Zappile, Paul; Wang, Guiqing; Plitnick, Jonathan; Griesemer, Sara B; Girardin, Roxanne; Machowski, Jessica; Bialosuknia, Sean; Lasek-Nesselquist, Erica; Hong, Samuel L; Baele, Guy; Dittmann, Meike; Ortigoza, Mila B; Prasad, Prithiv J; McDonough, Kathleen; Landau, Nathaniel R; St George, Kirsten; Heguy, Adriana.
  • Duerr R; Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA.
  • Zhou H; Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.
  • Tada T; Vaccine Center, NYU Grossman School of Medicine, New York, NY 10016, USA.
  • Dimartino D; Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA.
  • Marier C; Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA.
  • Zappile P; Genome Technology Center, Office of Science and Research, NYU Langone Health, New York, NY 10016, USA.
  • Wang G; Genome Technology Center, Office of Science and Research, NYU Langone Health, New York, NY 10016, USA.
  • Plitnick J; Genome Technology Center, Office of Science and Research, NYU Langone Health, New York, NY 10016, USA.
  • Griesemer SB; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA.
  • Girardin R; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
  • Machowski J; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
  • Bialosuknia S; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
  • Lasek-Nesselquist E; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
  • Hong SL; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
  • Baele G; Bioinformatics Core, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA.
  • Dittmann M; Biomedical Sciences Department, School of Public Health, University at Albany, SUNY, Albany, NY 12144, USA.
  • Ortigoza MB; Department of Microbiology, Immunology and Transplantation, Laboratory for Clinical and Epidemiological Virology, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
  • Prasad PJ; Department of Microbiology, Immunology and Transplantation, Laboratory for Clinical and Epidemiological Virology, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
  • McDonough K; Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA.
  • Landau NR; Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA.
  • St George K; Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.
  • Heguy A; Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.
iScience ; 26(2): 106075, 2023 Feb 17.
Article in English | MEDLINE | ID: covidwho-2240400
ABSTRACT
The emergence of recombinant viruses is a threat to public health, as recombination may integrate variant-specific features that together result in escape from treatment or immunity. The selective advantages of recombinant SARS-CoV-2 isolates over their parental lineages remain unknown. We identified a Delta-Omicron (AY.45-BA.1) recombinant in an immunosuppressed transplant recipient treated with monoclonal antibody Sotrovimab. The single recombination breakpoint is located in the spike N-terminal domain adjacent to the Sotrovimab binding site. While Delta and BA.1 are sensitive to Sotrovimab neutralization, the Delta-Omicron recombinant is highly resistant. To our knowledge, this is the first described instance of recombination between circulating SARS-CoV-2 variants as a functional mechanism of resistance to treatment and immune escape.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Variants Language: English Journal: IScience Year: 2023 Document Type: Article Affiliation country: J.isci.2023.106075

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Full text: Available Collection: International databases Database: MEDLINE Topics: Variants Language: English Journal: IScience Year: 2023 Document Type: Article Affiliation country: J.isci.2023.106075