Mechanisms of kidney injury in COVID-19 and diagnostic methods
Profilakticheskaya Meditsina
; 26(1):114-119, 2023.
Article
in Russian
| EMBASE | ID: covidwho-2240432
ABSTRACT
The COVID-19 pandemic is a global healthcare crisis. The frequency of acute kidney injury (AKI) in patients with COVID-19 and the features of its diagnostics indicate the relevance of the topic. Objective of the review. To analyze mechanisms of AKI development in patients with COVID-19 and provide support for methodological approaches to ensure its timely diagnosis. Material and methods. The methodological approaches used in the review are based on a sufficient number of literature sources (more than 150 sources), of which 34 articles are included in the review 15 original studies, 12 reviews, 2 meta-analyses, 5 re-ports, and letters to the editor. Results. The mechanisms of AKI development and progression, including the direct cytotoxic effect of the SARS-CoV-2 virus, dis-ruption of metabolic pathways of renal blood flow regulation, and the complement system, are considered. We also analyzed AKI risk factors in patients with acute respiratory distress diabetes mellitus, chronic kidney injury, arterial hypertension with im-paired NOx production, and eNOS expression as significant factors of vasodilation in renal microcirculatory vessels. The analy-sis showed the most perspective directions in the diagnostics of AKI functional stages. These include molecular test methods (pro-teome and metabolome) in blood and urine;they helped define damage markers to proximal tubules and the glomerular system, thus improving the diagnostics accuracy and validity, therapy efficiency, and end points of disease prognosis. Conclusion. The Coronado study aims to assess the phenotypic features of patients with diabetes mellitus and COVID-19. More specific markers of the acute kidney injury functional stage were determined;these markers will improve the diagnostics accuracy and validity, therapy efficiency, and end points of disease prognosis.
acute kidney failure; adult; chronic kidney failure; complement system; coronavirus disease 2019; cytotoxicity; diabetes mellitus; diabetic patient; diagnosis; diagnostic procedure; editor; endothelial dysfunction; female; gene expression; glomerulopathy; glomerulus; human; human tissue; hypertension; kidney blood flow; kidney proximal tubule; male; meta analysis; metabolome; nonhuman; prognosis; protein expression; respiratory distress; review; risk assessment; risk factor; Severe acute respiratory syndrome coronavirus 2; systematic review; validity; vasodilatation; cytokine; endogenous compound; endothelial nitric oxide synthase; proteome
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
Russian
Journal:
Profilakticheskaya Meditsina
Year:
2023
Document Type:
Article
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