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Variability in the Clinical Course of COVID-19 in a Retrospective Analysis of a Large Real-World Database.
Flisiak, Robert; Rzymski, Piotr; Zarebska-Michaluk, Dorota; Ciechanowski, Przemyslaw; Dobrowolska, Krystyna; Rogalska, Magdalena; Jaroszewicz, Jerzy; Szymanek-Pasternak, Anna; Rorat, Marta; Kozielewicz, Dorota; Kowalska, Justyna; Dutkiewicz, Ewa; Sikorska, Katarzyna; Moniuszko-Malinowska, Anna.
  • Flisiak R; Department of Infectious Diseases and Hepatology, Medical University of Bialystok, 15-540 Bialystok, Poland.
  • Rzymski P; Department of Environmental Medicine, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
  • Zarebska-Michaluk D; Department of Infectious Diseases, Jan Kochanowski University, 25-317 Kielce, Poland.
  • Ciechanowski P; Department of Paediatrics and Infectious Diseases, Regional Hospital in Szczecin, 71-455 Szczecin, Poland.
  • Dobrowolska K; Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland.
  • Rogalska M; Department of Infectious Diseases and Hepatology, Medical University of Bialystok, 15-540 Bialystok, Poland.
  • Jaroszewicz J; Department of Infectious Diseases and Hepatology, Medical University of Silesia in Katowice, 41-902 Bytom, Poland.
  • Szymanek-Pasternak A; Department of Infectious Diseases and Hepatology, Wroclaw Medical University, 51-149 Wroclaw, Poland.
  • Rorat M; Department of Forensic Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Kozielewicz D; Department of Infectious Diseases and Hepatology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Torun, Poland.
  • Kowalska J; Department of Adult's Infectious Diseases, Medical University of Warsaw, Hospital for Infectious Diseases, 02-091 Warsaw, Poland.
  • Dutkiewicz E; Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland.
  • Sikorska K; Division of Tropical and Parasitic Diseases, Faculty of Health Sciences, Medical University of Gdansk, 80-210 Gdansk, Poland.
  • Moniuszko-Malinowska A; Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-809 Bialystok, Poland.
Viruses ; 15(1)2023 Jan 03.
Article in English | MEDLINE | ID: covidwho-2240735
ABSTRACT
The COVID-19 pandemic proceeds in waves, with variable characteristics of the clinical picture resulting from the evolution of the SARS-CoV-2 virus. This study aimed to compare the epidemiological characteristics, symptomatology, and outcomes of the disease in patients hospitalized for COVID-19 during periods of different variants dominance. Comparing the periods of dominance of variants preceding the Delta variant, the Delta period was characterized by a higher share of hospitalized females, less frequent comorbidities among patients, and a different age distribution. The lowest need for oxygen therapy and mechanical ventilation was observed under Omicron dominance. The triad of classic COVID-19 symptoms, cough, fever, dyspnoea, and fatigue, were most prevalent during the Delta period, and significantly less common under the Omicron dominance. During the Omicron period, nearly twice as many patients as in the previous periods could be discharged from the hospital within 7 days; the overall 28-day mortality was significantly lower compared to that of the Delta period. It also did not differ between periods that were dominated by the BA.1 and BA.2 subvariants. The study indicates that the Omicron SARS-CoV-2 variant that dominated between January and June 2022 caused a disease which resembled the common cold, and was caused by seasonal alpha and beta-coronaviruses with a low pathogenicity for humans. However, one should note that this effect may not only have been related to biological features of the Omicron lineage, but may additionally have been driven by the increased levels of immunization through natural infections and vaccinations, for which we could not account for due to a lack of sufficient data.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Limits: Female / Humans Language: English Year: 2023 Document Type: Article Affiliation country: V15010149

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Limits: Female / Humans Language: English Year: 2023 Document Type: Article Affiliation country: V15010149