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Bilateral Lung Transplantation With Donor Positive for COVID-19 Infection on Bronchoalveolar Lavage: A Case Report.
Goetz, Ryan L; Nellore, Anoma; Geer, Jack T; Rusanov, Victoria; Wille, Keith; Scullin, Daniel; Orozco-Hernandez, Erik; Gongora, Enrique; Hoopes, Charles W; Kaleekal, Thomas S.
  • Goetz RL; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama. Electronic address: rgoetz@uabmc.edu.
  • Nellore A; Division of Infectious Diseases, Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama.
  • Geer JT; Division of Infectious Diseases, Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama.
  • Rusanov V; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama.
  • Wille K; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama.
  • Scullin D; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama.
  • Orozco-Hernandez E; Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama Birmingham, Birmingham, Alabama.
  • Gongora E; Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama Birmingham, Birmingham, Alabama.
  • Hoopes CW; Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama Birmingham, Birmingham, Alabama.
  • Kaleekal TS; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama.
Transplant Proc ; 55(3): 540-542, 2023 Apr.
Article in English | MEDLINE | ID: covidwho-2241031
ABSTRACT
Initial experience with lung transplant of COVID-19-positive donors was marked by disappointing results, including a reported case of mortality through donor to recipient transmission of infection. However, since that time a number of improvements in preventative and therapeutic measures against COVID-19 have been developed. We present the case of a 51-year-old woman with scleroderma-associated interstitial lung disease who was awaiting lung transplant. A potential donor with excellent lung physiology was located; however, initial testing on bronchoalveolar lavage (BAL) was positive for COVID-19. The donor had tested positive 2 weeks prior and had symptomatically recovered. Our patient had been fully vaccinated but not seroconverted. Given the history of a donor with recovering COVID infection and a fully immunized recipient, our multidisciplinary team elected to proceed with the transplant. The patient successfully underwent bilateral lung transplant with standard induction immunosuppression. Bebtelovimab was given post-transplant day 1 because the recipient remained seronegative to COVID-19. Serial bronchoalveolar lavages post transplant have been negative for COVID-19. The patient has done well after transplant. She was seen in the clinic 2 months post transplant and is ambulatory without supplemental oxygen requirements. To our knowledge, this represents the first reported successful case of lung transplant with a donor positive for COVID-19 on lower respiratory tract sampling.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lung Transplantation / COVID-19 Type of study: Case report / Prognostic study Topics: Vaccines Limits: Female / Humans / Middle aged Language: English Journal: Transplant Proc Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lung Transplantation / COVID-19 Type of study: Case report / Prognostic study Topics: Vaccines Limits: Female / Humans / Middle aged Language: English Journal: Transplant Proc Year: 2023 Document Type: Article