[Pathophysiology of sepsis]. / Pathophysiologie der Sepsis.
Anasthesiol Intensivmed Notfallmed Schmerzther
; 58(1): 13-27, 2023 Jan.
Article
in German
| MEDLINE | ID: covidwho-2241115
ABSTRACT
Up to now, sepsis is one of the most threatening diseases and its therapy remains challenging. Sepsis is currently defined as a severely dysregulated immune response to an infection resulting in organ dysfunction. The pathophysiology is mainly driven by exogenous PAMPs ("pathogen-associated molecular patterns") and endogenous DAMPs ("damage-associated molecular patterns"), which can activate PRRs ("pattern recognition receptors") on different cell types (mainly immune cells), leading to the initiation of manifold downstream pathways and a perpetuation of patients' immune response. Sepsis is neither an exclusive pro- nor an anti-inflammatory disease both processes take place in parallel, resulting in an individual immunologic disease state depending on the severity of each component at different time points. Septic shock is a complex disorder of the macro- and microcirculation, provoking a severe lack of oxygenation further aggravating sepsis defining organ dysfunctions. An in-depth knowledge of the heterogeneity and the time-dependency of the septic immunopathology will be essential for the design of future sepsis trials and therapy planning in patients with sepsis. The big aim is to achieve a more individualized treatment strategy in patients suffering from sepsis or septic shock.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Shock, Septic
/
Sepsis
Type of study:
Prognostic study
Limits:
Humans
Language:
German
Journal:
Anasthesiol Intensivmed Notfallmed Schmerzther
Journal subject:
Anesthesiology
/
Emergency Medicine
/
Critical Care
Year:
2023
Document Type:
Article
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