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Remdesivir resistance in transplant recipients with persistent COVID-19.
Hogan, John I; Duerr, Ralf; Dimartino, Dacia; Marier, Christian; Hochman, Sarah E; Mehta, Sapna; Wang, Guiqing; Heguy, Adriana.
  • Hogan JI; Department of Medicine NYU Long Island School of Medicine Mineola, New York  United States of America.
  • Duerr R; Department of Microbiology NYU Grossman School of Medicine New York, New York  United States of America.
  • Dimartino D; Genome Technology Center NYU Langone Health New York, New York  United States of America.
  • Marier C; Genome Technology Center NYU Langone Health New York, New York  United States of America.
  • Hochman SE; Department of Medicine NYU Grossman School of Medicine New York, New York  United States of America.
  • Mehta S; Department of Medicine NYU Grossman School of Medicine New York, New York  United States of America.
  • Wang G; Department of Pathology NYU Grossman School of Medicine New York, New York  United States of America.
  • Heguy A; Department of Pathology NYU Grossman School of Medicine New York, New York  United States of America.
Clin Infect Dis ; 2022 Sep 26.
Article in English | MEDLINE | ID: covidwho-2241485
ABSTRACT
New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Long Covid Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Long Covid Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article